Synthesis and DNase I Inhibitory Properties of New Squaramides

Synthesis and DNase I Inhibitory Properties of New Squaramides

Three new monosquaramides (<b>3a</b>–<b>c</b>) were synthesized, characterized by IR, NMR and X-ray, and evaluated for inhibitory activity against deoxyribonuclease I (DNase I) and xanthine oxidase (XO) in vitro. The target compounds inhibited DNase I with IC<sub>50<...

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Bibliographic Details
Main Authors: Nina Ruseva, Hristina Sbirkova-Dimitrova, Mariyana Atanasova, Ana Marković, Žaklina Šmelcerović, Andrija Šmelcerović, Adriana Bakalova, Emiliya Cherneva
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
monosquaramides
DNase I inhibition
XO inhibition
docking studies
Online Access:https://www.mdpi.com/1420-3049/28/2/538

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