Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results
Introduction: Detrusor injection with onabotulinumtoxin A (OnabotA-DI) is an established therapy for overactive bladder (OAB). Little is known about the exact onset and course of the effect in the days after the injection therapy. By using a new type of app-controlled automated diary pod, for the fi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/1/30 |
| _version_ | 1797436700423618560 |
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| author | Heinrich Schulte-Baukloh Catarina Weiß Sarah Weinberger Mandy Hubatsch Thorsten Schlomm Bernhard Ralla |
| author_facet | Heinrich Schulte-Baukloh Catarina Weiß Sarah Weinberger Mandy Hubatsch Thorsten Schlomm Bernhard Ralla |
| author_sort | Heinrich Schulte-Baukloh |
| collection | DOAJ |
| description | Introduction: Detrusor injection with onabotulinumtoxin A (OnabotA-DI) is an established therapy for overactive bladder (OAB). Little is known about the exact onset and course of the effect in the days after the injection therapy. By using a new type of app-controlled automated diary pod, for the first time, the precise onset of the effect of OnabotA-DI can be documented in real time. Materials and methods: Patients due for OnabotA-DI were asked to document voiding 3 days before and up to 3 weeks after therapy using the Diary Pod app. The detrusor injection was performed with onabotulinumtoxin A (Botox<sup>®</sup>), 100 units, at 20 sites of the detrusor muscle in a standardized manner. Voiding on the injection day itself was not documented. Results: A total of 17 patients (15 women, 2 men; aged 33–83 (mean 64.6; median 70) years) were included in the study. The handling of the Diary Pod app was user-friendly, and elderly patients did not encounter technical problems. The results of patients with reliably documented micturitions showed a continuous reduction in micturition frequency every day from the first day and significantly from day 5. For 24 h voiding, from 12.83 ± 5.54 in the 3 days before injection, the following mean values were found with significant (<i>p</i> < 0.05) changes after the intervention: 9.17 ± 3.19 on day 5, 8.75 ± 3.69 on day 10, 7.17 ± 2.04 on day 15, and 5.75 ± 0.5 on day 20. These changes were in similar proportions during the daytime and nighttime. Conclusions: Contrary to previous knowledge, the effect of the OnabotA-DI set in from the first postoperative days and was reflected a similar extent in day and night micturition. This study is the first to document the onset of action of OnabotA-DI in real time. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T11:06:21Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-9a64158b0206417d9c80605b1df3080d2023-12-01T00:56:46ZengMDPI AGToxins2072-66512022-12-011513010.3390/toxins15010030Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary ResultsHeinrich Schulte-Baukloh0Catarina Weiß1Sarah Weinberger2Mandy Hubatsch3Thorsten Schlomm4Bernhard Ralla5Department of Urology, Charité Universitätsmedizin Berlin, 10117 Berlin, GermanyUrologic Practice, Kurfürstendamm 139, 10711 Berlin, GermanyDepartment of Urology, Charité Universitätsmedizin Berlin, 10117 Berlin, GermanyDepartment of Urology, Charité Universitätsmedizin Berlin, 10117 Berlin, GermanyDepartment of Urology, Charité Universitätsmedizin Berlin, 10117 Berlin, GermanyDepartment of Urology, Charité Universitätsmedizin Berlin, 10117 Berlin, GermanyIntroduction: Detrusor injection with onabotulinumtoxin A (OnabotA-DI) is an established therapy for overactive bladder (OAB). Little is known about the exact onset and course of the effect in the days after the injection therapy. By using a new type of app-controlled automated diary pod, for the first time, the precise onset of the effect of OnabotA-DI can be documented in real time. Materials and methods: Patients due for OnabotA-DI were asked to document voiding 3 days before and up to 3 weeks after therapy using the Diary Pod app. The detrusor injection was performed with onabotulinumtoxin A (Botox<sup>®</sup>), 100 units, at 20 sites of the detrusor muscle in a standardized manner. Voiding on the injection day itself was not documented. Results: A total of 17 patients (15 women, 2 men; aged 33–83 (mean 64.6; median 70) years) were included in the study. The handling of the Diary Pod app was user-friendly, and elderly patients did not encounter technical problems. The results of patients with reliably documented micturitions showed a continuous reduction in micturition frequency every day from the first day and significantly from day 5. For 24 h voiding, from 12.83 ± 5.54 in the 3 days before injection, the following mean values were found with significant (<i>p</i> < 0.05) changes after the intervention: 9.17 ± 3.19 on day 5, 8.75 ± 3.69 on day 10, 7.17 ± 2.04 on day 15, and 5.75 ± 0.5 on day 20. These changes were in similar proportions during the daytime and nighttime. Conclusions: Contrary to previous knowledge, the effect of the OnabotA-DI set in from the first postoperative days and was reflected a similar extent in day and night micturition. This study is the first to document the onset of action of OnabotA-DI in real time.https://www.mdpi.com/2072-6651/15/1/30overactive bladderbotulinum toxinurinary incontinenceurinary bladderinjectionsintramuscular |
| spellingShingle | Heinrich Schulte-Baukloh Catarina Weiß Sarah Weinberger Mandy Hubatsch Thorsten Schlomm Bernhard Ralla Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results Toxins overactive bladder botulinum toxin urinary incontinence urinary bladder injections intramuscular |
| title | Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results |
| title_full | Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results |
| title_fullStr | Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results |
| title_full_unstemmed | Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results |
| title_short | Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results |
| title_sort | real time documentation of the effect of onabotulinumtoxin a detrusor injection in oab patients preliminary results |
| topic | overactive bladder botulinum toxin urinary incontinence urinary bladder injections intramuscular |
| url | https://www.mdpi.com/2072-6651/15/1/30 |
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