Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.

Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.

Danforth's short tail (Sd) is a semidominant mutation on mouse chromosome 2, characterized by spinal defects, urogenital defects, and anorectal malformations. However, the gene responsible for the Sd phenotype was unknown. In this study, we identified the molecular basis of the Sd mutation. By...

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Detalles Bibliográficos
Main Authors: Kei Semba, Kimi Araki, Ken-ichirou Matsumoto, Hiroko Suda, Takashi Ando, Akira Sei, Hiroshi Mizuta, Katsumasa Takagi, Mai Nakahara, Mayumi Muta, Gen Yamada, Naomi Nakagata, Aritoshi Iida, Shiro Ikegawa, Yusuke Nakamura, Masatake Araki, Kuniya Abe, Ken-ichi Yamamura
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Acceso en liña:http://europepmc.org/articles/PMC3578775?pdf=render

Internet

http://europepmc.org/articles/PMC3578775?pdf=render

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