Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing
Abstract Endoscopic tattooing with India ink is a popular method for identifying colonic lesions during minimally invasive surgery because it is highly challenging to localize lesions during laparoscopy. However, there is a perceived unmet need for the injection of India ink and carbon particle susp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28113-1 |
| _version_ | 1811171772583641088 |
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| author | Hyung Jun Kwon Hyun Ho Shin Da Han Hyun Ghilsuk Yoon Jun Seok Park Ji Hyun Ryu |
| author_facet | Hyung Jun Kwon Hyun Ho Shin Da Han Hyun Ghilsuk Yoon Jun Seok Park Ji Hyun Ryu |
| author_sort | Hyung Jun Kwon |
| collection | DOAJ |
| description | Abstract Endoscopic tattooing with India ink is a popular method for identifying colonic lesions during minimally invasive surgery because it is highly challenging to localize lesions during laparoscopy. However, there is a perceived unmet need for the injection of India ink and carbon particle suspension due to various complications and inconstant durability during the perioperative period. In this study, carbon black-containing self-healing adhesive alginate/polyvinyl alcohol composite hydrogels were synthesized as endoscopic tattooing inks. Alginate (Alg) conjugated with phenylboronic acid (PBA) groups in the backbone was crosslinked with polyvinyl alcohol (PVA) because of the dynamic bonds between the phenylboronic acid in alginate and the cis-diol groups of PVA. The carbon black-incorporated Alg-PBA/PVA hydrogels exhibited self-healing and re-shapable properties, indicating that improved intraoperative localization could be achieved. In addition, the adhesive tattooing hydrogels were stably immobilized on the target regions in the intraperitoneal spaces. These carbon black-containing self-healing adhesive hydrogels are expected to be useful in various surgical procedures, including endoscopic tattooing. |
| first_indexed | 2024-04-10T17:19:37Z |
| format | Article |
| id | doaj.art-9a64d631d99c4387b7d1d5133a02a405 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T17:19:37Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9a64d631d99c4387b7d1d5133a02a4052023-02-05T12:11:39ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-28113-1Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooingHyung Jun Kwon0Hyun Ho Shin1Da Han Hyun2Ghilsuk Yoon3Jun Seok Park4Ji Hyun Ryu5Department of Surgery, School of Medicine, Kyungpook National University Hospital, Kyungpook National UniversityDepartment of Chemical Engineering, Wonkwang UniversityDepartment of Biomedical Science, School of Medicine, Kyungpook National UniversityDepartment of Pathology, School of Medicine, Kyungpook National UniversityDepartment of Surgery, School of Medicine, Kyungpook National University Hospital, Kyungpook National UniversityDepartment of Carbon Convergence Engineering, Wonkwang UniversityAbstract Endoscopic tattooing with India ink is a popular method for identifying colonic lesions during minimally invasive surgery because it is highly challenging to localize lesions during laparoscopy. However, there is a perceived unmet need for the injection of India ink and carbon particle suspension due to various complications and inconstant durability during the perioperative period. In this study, carbon black-containing self-healing adhesive alginate/polyvinyl alcohol composite hydrogels were synthesized as endoscopic tattooing inks. Alginate (Alg) conjugated with phenylboronic acid (PBA) groups in the backbone was crosslinked with polyvinyl alcohol (PVA) because of the dynamic bonds between the phenylboronic acid in alginate and the cis-diol groups of PVA. The carbon black-incorporated Alg-PBA/PVA hydrogels exhibited self-healing and re-shapable properties, indicating that improved intraoperative localization could be achieved. In addition, the adhesive tattooing hydrogels were stably immobilized on the target regions in the intraperitoneal spaces. These carbon black-containing self-healing adhesive hydrogels are expected to be useful in various surgical procedures, including endoscopic tattooing.https://doi.org/10.1038/s41598-023-28113-1 |
| spellingShingle | Hyung Jun Kwon Hyun Ho Shin Da Han Hyun Ghilsuk Yoon Jun Seok Park Ji Hyun Ryu Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing Scientific Reports |
| title | Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing |
| title_full | Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing |
| title_fullStr | Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing |
| title_full_unstemmed | Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing |
| title_short | Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing |
| title_sort | carbon black containing self healing adhesive hydrogels for endoscopic tattooing |
| url | https://doi.org/10.1038/s41598-023-28113-1 |
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