Global, regional, and national burden of heart failure associated with atrial fibrillation
Abstract Background Heart failure is a leading cause of mortality and morbidity worldwide, and Atrial fibrillation (AF) is among many modifiable risk factors for heart failure. No estimates are available on the magnitude of the burden of heart failure associated with AF, and this study estimated the...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03375-9 |
| _version_ | 1797779067220525056 |
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| author | Sanjeewa Kularatna Amarzaya Jadambaa Sumudu Hewage David Brain Steven McPhail William Parsonage |
| author_facet | Sanjeewa Kularatna Amarzaya Jadambaa Sumudu Hewage David Brain Steven McPhail William Parsonage |
| author_sort | Sanjeewa Kularatna |
| collection | DOAJ |
| description | Abstract Background Heart failure is a leading cause of mortality and morbidity worldwide, and Atrial fibrillation (AF) is among many modifiable risk factors for heart failure. No estimates are available on the magnitude of the burden of heart failure associated with AF, and this study estimated the global, regional, and national burdens associated with AF. Methods We used the comparative risk assessment method to estimate the disease burden in terms of prevalence and years lived with disability (YLD). The population-attributable fraction for heart failure and AF was calculated from prevalence estimates of AF and the recalculated relative risks of heart failure associated with AF from a systematic review summarising the longitudinal association between AF and outcomes. The burden of heart failure was retrieved from the Global Burden of Disease database. Results Globally, 2.6% (95% uncertainty interval 1.3 to 4.7%) of the burden of heart failure is associated with AF. This was 1.5 (95% UI 0.6 to 3.2) million people in 2019, a 49.8% increase from 1990. The highest prevalence was from South-East Asia, East Asia and Oceania. The highest YLD was estimated for Central Europe, Eastern Europe and Central Asia. High-income countries showed a sharp decline in the age standardised prevalence and YLD rates from 1990 to 2019. Conclusion The burden of heart failure associated with AF has increased substantially over the past two decades despite the advances in AF management. However, falling prevalence and YLD rates of heart failure associated with AF in high-income countries over time indicate that reducing this burden is possible. |
| first_indexed | 2024-03-12T23:26:23Z |
| format | Article |
| id | doaj.art-9a6527f4527642b2b36908d5acd89348 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-12T23:26:23Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-9a6527f4527642b2b36908d5acd893482023-07-16T11:08:58ZengBMCBMC Cardiovascular Disorders1471-22612023-07-0123111110.1186/s12872-023-03375-9Global, regional, and national burden of heart failure associated with atrial fibrillationSanjeewa Kularatna0Amarzaya Jadambaa1Sumudu Hewage2David Brain3Steven McPhail4William Parsonage5Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of TechnologyAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of TechnologyAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of TechnologyAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of TechnologyAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of TechnologyAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of TechnologyAbstract Background Heart failure is a leading cause of mortality and morbidity worldwide, and Atrial fibrillation (AF) is among many modifiable risk factors for heart failure. No estimates are available on the magnitude of the burden of heart failure associated with AF, and this study estimated the global, regional, and national burdens associated with AF. Methods We used the comparative risk assessment method to estimate the disease burden in terms of prevalence and years lived with disability (YLD). The population-attributable fraction for heart failure and AF was calculated from prevalence estimates of AF and the recalculated relative risks of heart failure associated with AF from a systematic review summarising the longitudinal association between AF and outcomes. The burden of heart failure was retrieved from the Global Burden of Disease database. Results Globally, 2.6% (95% uncertainty interval 1.3 to 4.7%) of the burden of heart failure is associated with AF. This was 1.5 (95% UI 0.6 to 3.2) million people in 2019, a 49.8% increase from 1990. The highest prevalence was from South-East Asia, East Asia and Oceania. The highest YLD was estimated for Central Europe, Eastern Europe and Central Asia. High-income countries showed a sharp decline in the age standardised prevalence and YLD rates from 1990 to 2019. Conclusion The burden of heart failure associated with AF has increased substantially over the past two decades despite the advances in AF management. However, falling prevalence and YLD rates of heart failure associated with AF in high-income countries over time indicate that reducing this burden is possible.https://doi.org/10.1186/s12872-023-03375-9Heart failureAtrial fibrillationGlobal burdenRegional burdenNational burdenPopulation attributable fraction |
| spellingShingle | Sanjeewa Kularatna Amarzaya Jadambaa Sumudu Hewage David Brain Steven McPhail William Parsonage Global, regional, and national burden of heart failure associated with atrial fibrillation BMC Cardiovascular Disorders Heart failure Atrial fibrillation Global burden Regional burden National burden Population attributable fraction |
| title | Global, regional, and national burden of heart failure associated with atrial fibrillation |
| title_full | Global, regional, and national burden of heart failure associated with atrial fibrillation |
| title_fullStr | Global, regional, and national burden of heart failure associated with atrial fibrillation |
| title_full_unstemmed | Global, regional, and national burden of heart failure associated with atrial fibrillation |
| title_short | Global, regional, and national burden of heart failure associated with atrial fibrillation |
| title_sort | global regional and national burden of heart failure associated with atrial fibrillation |
| topic | Heart failure Atrial fibrillation Global burden Regional burden National burden Population attributable fraction |
| url | https://doi.org/10.1186/s12872-023-03375-9 |
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