Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that increases this activity. These studies demonstrate...

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Bibliographic Details
Main Authors: Yunxiang Mu, Kevin M. McBride
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Molecular & Cellular Oncology
Subjects:
aicda
activation-induced cytidine deaminase
b cells
class switch recombination
chromosome translocation
lithium
lymphoma
mutation
myc
Online Access:http://dx.doi.org/10.1080/23723556.2018.1432259
Description
Summary:The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that increases this activity. These studies demonstrate how dysregulating AID phosphorylation can promote oncogenesis.
ISSN:2372-3556

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