Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice.

Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice.

AMP-activated protein kinase (AMPK) is an energy sensor of metabolism that is an attractive therapeutic target for type 2 diabetes mellitus and metabolic syndrome. Using a homogeneous scintillation proximity assay (SPA), we identified a new small-molecule AMPK activator, ZLN024, which allosterically...

Full description

Bibliographic Details
Main Authors:	Li-Na Zhang, Lei Xu, Hua-Yong Zhou, Ling-Yan Wu, Yuan-Yuan Li, Tao Pang, Chun-Mei Xia, Bei-Ying Qiu, Min Gu, Tian-Cheng Dong, Jing-Ya Li, Jing-Kang Shen, Jia Li
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3748009?pdf=render

Similar Items

Mulberry leaf extract displays antidiabetic activity in db/db mice via Akt and AMP-activated protein kinase phosphorylation
by: Ui-Jin Bae, et al.
Published: (2018-08-01)

Beneficial Effects of Echinacoside on Diabetic Cardiomyopathy in Diabetic Db/Db Mice
by: Zhang X, et al.
Published: (2020-12-01)

Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice
by: Li Luo, et al.
Published: (2019-01-01)

QiDiTangShen Granules Activate Renal Nutrient-Sensing Associated Autophagy in db/db Mice
by: Xiangming Wang, et al.
Published: (2019-10-01)

Dapagliflozin Ameliorates Diabetic Kidney Disease via Upregulating Crry and Alleviating Complement Over-activation in db/db Mice
by: Dong-Yuan Chang, et al.
Published: (2021-10-01)

S-Propargyl-Cysteine Attenuates Diabetic Cardiomyopathy in db/db Mice Through Activation of Cardiac Insulin Receptor Signaling
by: Ye Li, et al.
Published: (2021-09-01)

Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice
by: Zeng H, et al.
Published: (2021-07-01)

Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice
by: Mei-Ling Su, et al.
Published: (2016-07-01)

Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
by: Shao Y, et al.
Published: (2015-02-01)

Protective effects of astragaloside IV on db/db mice with diabetic retinopathy.
by: Yuzhi Ding, et al.
Published: (2014-01-01)

Mibefradil reduces blood glucose concentration in db/db mice
by: Yujie Lu, et al.
Published: (2014-01-01)

Neuregulin 1 Improves Glucose Tolerance in db/db Mice.
by: Gaël Ennequin, et al.
Published: (2015-01-01)

AI Meets Database: AI4DB and DB4AI
by: Li, Guoliang, et al.
Published: (2022)

Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice
by: Wenhua Xue, et al.
Published: (2018-03-01)

Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice
by: Fu W, et al.
Published: (2020-05-01)

Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver
by: You Wu, et al.
Published: (2022-11-01)

Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice
by: Panshuang Qiao, et al.
Published: (2022-08-01)

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice
by: Di Wang, et al.
Published: (2019-05-01)

NewSQL Databases Assessment: CockroachDB, MariaDB Xpand, and VoltDB
by: Eduardo Pina, et al.
Published: (2022-12-01)

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice
by: Qianbo Song, et al.
Published: (2022-11-01)

The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice
by: Bing Li, et al.
Published: (2024-03-01)

Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK–Mitophagy–Apoptosis
by: Zhe Zhang, et al.
Published: (2022-08-01)

Polydatin Alleviates Diabetes-Induced Hyposalivation through Anti-Glycation Activity in db/db Mouse
by: Hyung Rae Kim, et al.
Published: (2021-12-01)

A sulfonamide chalcone AMPK activator ameliorates hyperglycemia and diabetic nephropathy in db/db mice
by: Suchada Kaewin, et al.
Published: (2023-09-01)

1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice
by: Qingpu Liu, et al.
Published: (2016-02-01)

Pulsed electromagnetic fields inhibit mandibular bone deterioration depending on the Wnt3a/β-catenin signaling activation in type 2 diabetic db/db mice
by: Jianjun Li, et al.
Published: (2022-05-01)

Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis
by: Junhui Gu, et al.
Published: (2016-11-01)

Ethoxyquin is neuroprotective and partially prevents somatic and autonomic neuropathy in db/db mouse model of type 2 diabetes
by: Ying Liu, et al.
Published: (2021-05-01)

Corrigendum: 9-PAHSA Improves Cardiovascular Complications by Promoting Autophagic Flux and Reducing Myocardial Hypertrophy in Db/Db Mice
by: Yan-Mei Wang, et al.
Published: (2022-01-01)

Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice
by: Xue M, et al.
Published: (2015-08-01)

Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice
by: Hiro Yamamoto, et al.
Published: (2022-09-01)

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
by: Yadong Zhai, et al.
Published: (2018-02-01)

Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice.
by: Yu Ah Hong, et al.
Published: (2014-01-01)

Gut Microbiota Alteration Is Associated With Cognitive Deficits in Genetically Diabetic (Db/db) Mice During Aging
by: Jiawei Zhang, et al.
Published: (2022-01-01)

Inhibition of p38 mitogen-activated protein kinase exerts a hypoglycemic effect by improving β cell function via inhibition of β cell apoptosis in db/db mice
by: Xiaowei Wei, et al.
Published: (2018-01-01)

Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice
by: Huan Wang, et al.
Published: (2023-04-01)

Empagliflozin inhibits coronary microvascular dysfunction and reduces cardiac pericyte loss in db/db mice
by: Yimin Tu, et al.
Published: (2022-12-01)

Effects of D-Chiro-Inositol on Glucose Metabolism in db/db Mice and the Associated Underlying Mechanisms
by: Chunxue Fan, et al.
Published: (2020-03-01)

Analysis of bone metabolic alterations linked with osteoporosis progression in type 2 diabetic db/db mice
by: Kefeng Wu, et al.
Published: (2024-01-01)

Astaxanthin Attenuates the Apoptosis of Retinal Ganglion Cells in db/db Mice by Inhibition of Oxidative Stress
by: Xiao-Li Kang, et al.
Published: (2013-03-01)