The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction
Abstract Background Ventricular arrhythmias cause a significant proportion of sudden deaths. Several studies demonstrate a high prevalence of ventricular arrhythmias in patients with heart failure regardless of the etiology. The aim of this study was to determine the prevalence of silent ventricular...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-02-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | https://doi.org/10.1186/s43044-022-00247-z |
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| author | Mohamed Sanhoury Fatema Mohamed Mohamed Sadaka Mohamed Ayman Abdel-Hay Mohamed Sobhy Mostafa Elwany |
| author_facet | Mohamed Sanhoury Fatema Mohamed Mohamed Sadaka Mohamed Ayman Abdel-Hay Mohamed Sobhy Mostafa Elwany |
| author_sort | Mohamed Sanhoury |
| collection | DOAJ |
| description | Abstract Background Ventricular arrhythmias cause a significant proportion of sudden deaths. Several studies demonstrate a high prevalence of ventricular arrhythmias in patients with heart failure regardless of the etiology. The aim of this study was to determine the prevalence of silent ventricular arrhythmias in ambulatory heart failure patients with reduced left ventricular ejection fraction (HFrEF) and its correlation to the prognosis. Results Four hundred (400) ambulatory HFrEF patients on maximum tolerated doses of heart failure medications were included. Holter monitoring for 7 days was done in all patients searching for silent ventricular arrhythmias. The patients were followed-up for one year to detect the occurrence of major adverse cardiovascular events. We divided the study population into 2 groups based on an LVEF cutoff value of 30% (Group A < 30%, Group B ≥ 30%). Holter monitoring revealed ventricular arrhythmias in 304 patients. Patients with left ventricular ejection fraction (EF) < 30% (Group A) had more complex ventricular arrhythmias in the form of frequent Premature ventricular contractions (PVCs) of ≥ 5% and or non-sustained ventricular tachycardia (NSVT) runs. Furthermore, Among Group A, more major cardiovascular events were observed. Multivariate regression analysis showed that frequent PVCs and severely reduced LVEF were the strongest independent predictors of major cardiovascular events. Conclusions ventricular arrhythmias are common in HFrEF patients even in the compensated status. Both, left ventricular systolic function and the PVCs burden were found to be the strongest predictors of major adverse cardiovascular events. |
| first_indexed | 2024-12-24T00:32:31Z |
| format | Article |
| id | doaj.art-9a68b61390b34be48c71b5f3ee38aad2 |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-12-24T00:32:31Z |
| publishDate | 2022-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-9a68b61390b34be48c71b5f3ee38aad22022-12-21T17:24:12ZengSpringerOpenThe Egyptian Heart Journal2090-911X2022-02-017411710.1186/s43044-022-00247-zThe impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fractionMohamed Sanhoury0Fatema Mohamed1Mohamed Sadaka2Mohamed Ayman Abdel-Hay3Mohamed Sobhy4Mostafa Elwany5Cardiology and Angiology Department, Faculty of Medicine, University of AlexandriaCardiology and Angiology Department, Faculty of Medicine, University of AlexandriaCardiology and Angiology Department, Faculty of Medicine, University of AlexandriaCardiology and Angiology Department, Faculty of Medicine, University of AlexandriaCardiology and Angiology Department, Faculty of Medicine, University of AlexandriaCardiology and Angiology Department, Faculty of Medicine, University of AlexandriaAbstract Background Ventricular arrhythmias cause a significant proportion of sudden deaths. Several studies demonstrate a high prevalence of ventricular arrhythmias in patients with heart failure regardless of the etiology. The aim of this study was to determine the prevalence of silent ventricular arrhythmias in ambulatory heart failure patients with reduced left ventricular ejection fraction (HFrEF) and its correlation to the prognosis. Results Four hundred (400) ambulatory HFrEF patients on maximum tolerated doses of heart failure medications were included. Holter monitoring for 7 days was done in all patients searching for silent ventricular arrhythmias. The patients were followed-up for one year to detect the occurrence of major adverse cardiovascular events. We divided the study population into 2 groups based on an LVEF cutoff value of 30% (Group A < 30%, Group B ≥ 30%). Holter monitoring revealed ventricular arrhythmias in 304 patients. Patients with left ventricular ejection fraction (EF) < 30% (Group A) had more complex ventricular arrhythmias in the form of frequent Premature ventricular contractions (PVCs) of ≥ 5% and or non-sustained ventricular tachycardia (NSVT) runs. Furthermore, Among Group A, more major cardiovascular events were observed. Multivariate regression analysis showed that frequent PVCs and severely reduced LVEF were the strongest independent predictors of major cardiovascular events. Conclusions ventricular arrhythmias are common in HFrEF patients even in the compensated status. Both, left ventricular systolic function and the PVCs burden were found to be the strongest predictors of major adverse cardiovascular events.https://doi.org/10.1186/s43044-022-00247-zHeart failureVentricular arrhythmiasPrognosis |
| spellingShingle | Mohamed Sanhoury Fatema Mohamed Mohamed Sadaka Mohamed Ayman Abdel-Hay Mohamed Sobhy Mostafa Elwany The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction The Egyptian Heart Journal Heart failure Ventricular arrhythmias Prognosis |
| title | The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction |
| title_full | The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction |
| title_fullStr | The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction |
| title_full_unstemmed | The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction |
| title_short | The impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction |
| title_sort | impact of asymptomatic ventricular arrhythmias on the outcome of heart failure patients with reduced ejection fraction |
| topic | Heart failure Ventricular arrhythmias Prognosis |
| url | https://doi.org/10.1186/s43044-022-00247-z |
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