Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

Summary: Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is indispensable for specific ligand binding. This art...

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Bibliographic Details
Main Authors: Huixia Wang, Wanhui Hu, Tiandan Xu, Ya Yuan, Dongsheng Liu, Kurt Wüthrich
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Biological sciences
molecular biology
molecular structure
molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223009951

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http://www.sciencedirect.com/science/article/pii/S2589004223009951

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