Colonic TRPV4 overexpression is related to constipation severity

Colonic TRPV4 overexpression is related to constipation severity

Abstract Background Chronic constipation is prevalent and involves both colon sensitivity and various changes in intestinal bacteria, particularly mucosa-associated microflora. Here we examined regulatory mechanisms of TRPV4 expression by co-culturing colon epithelial cell lines with intestinal bact...

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Bibliographic Details
Main Authors: Hiroshi Mihara, Kunitoshi Uchida, Yoshiyuki Watanabe, Sohachi Nanjo, Miho Sakumura, Iori Motoo, Takayuki Ando, Masami Minemura, Jibran Sualeh Muhammad, Hiroyuki Yamamoto, Fumio Itoh, Ichiro Yasuda
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Gastroenterology
Subjects:
Colon
TRPV4
E. faecalis
E. coli
Chronic constipation
Online Access:https://doi.org/10.1186/s12876-023-02647-0

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