The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration
RNA-binding proteins (RBPs) are a class of proteins known for their diverse roles in RNA biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation in the cytoplasm. With higher demand for RNA metabolism in the nervous system, RBP misregulation has been linked t...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/19/7151 |
| _version_ | 1797552362638802944 |
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| author | Yee Wa Lim Dylan James Jie Huang Mihwa Lee |
| author_facet | Yee Wa Lim Dylan James Jie Huang Mihwa Lee |
| author_sort | Yee Wa Lim |
| collection | DOAJ |
| description | RNA-binding proteins (RBPs) are a class of proteins known for their diverse roles in RNA biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation in the cytoplasm. With higher demand for RNA metabolism in the nervous system, RBP misregulation has been linked to a wide range of neurological and neurodegenerative diseases. One of the emerging RBPs implicated in neuronal function and neurodegeneration is splicing factor proline- and glutamine-rich (SFPQ). SFPQ is a ubiquitous and abundant RBP that plays multiple regulatory roles in the nucleus such as paraspeckle formation, DNA damage repair, and various transcriptional regulation processes. An increasing number of studies have demonstrated the nuclear and also cytoplasmic roles of SFPQ in neurons, particularly in post-transcriptional regulation and RNA granule formation. Not surprisingly, the misregulation of SFPQ has been linked to pathological features shown by other neurodegenerative disease-associated RBPs such as aberrant RNA splicing, cytoplasmic mislocalization, and aggregation. In this review, we discuss recent findings on the roles of SFPQ with a particular focus on those in neuronal development and homeostasis as well as its implications in neurodegenerative diseases. |
| first_indexed | 2024-03-10T15:59:58Z |
| format | Article |
| id | doaj.art-9a6ac1832b4f4e18940e49d4f13256dc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:59:58Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9a6ac1832b4f4e18940e49d4f13256dc2023-11-20T15:22:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012119715110.3390/ijms21197151The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and NeurodegenerationYee Wa Lim0Dylan James1Jie Huang2Mihwa Lee3Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, AustraliaDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, AustraliaDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, AustraliaDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, AustraliaRNA-binding proteins (RBPs) are a class of proteins known for their diverse roles in RNA biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation in the cytoplasm. With higher demand for RNA metabolism in the nervous system, RBP misregulation has been linked to a wide range of neurological and neurodegenerative diseases. One of the emerging RBPs implicated in neuronal function and neurodegeneration is splicing factor proline- and glutamine-rich (SFPQ). SFPQ is a ubiquitous and abundant RBP that plays multiple regulatory roles in the nucleus such as paraspeckle formation, DNA damage repair, and various transcriptional regulation processes. An increasing number of studies have demonstrated the nuclear and also cytoplasmic roles of SFPQ in neurons, particularly in post-transcriptional regulation and RNA granule formation. Not surprisingly, the misregulation of SFPQ has been linked to pathological features shown by other neurodegenerative disease-associated RBPs such as aberrant RNA splicing, cytoplasmic mislocalization, and aggregation. In this review, we discuss recent findings on the roles of SFPQ with a particular focus on those in neuronal development and homeostasis as well as its implications in neurodegenerative diseases.https://www.mdpi.com/1422-0067/21/19/7151SFPQDBHS protein family<i>Drosophila</i> behavior human splicingRNA-binding proteinnuclear proteinneurodegenerative disease |
| spellingShingle | Yee Wa Lim Dylan James Jie Huang Mihwa Lee The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration International Journal of Molecular Sciences SFPQ DBHS protein family <i>Drosophila</i> behavior human splicing RNA-binding protein nuclear protein neurodegenerative disease |
| title | The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration |
| title_full | The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration |
| title_fullStr | The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration |
| title_full_unstemmed | The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration |
| title_short | The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration |
| title_sort | emerging role of the rna binding protein sfpq in neuronal function and neurodegeneration |
| topic | SFPQ DBHS protein family <i>Drosophila</i> behavior human splicing RNA-binding protein nuclear protein neurodegenerative disease |
| url | https://www.mdpi.com/1422-0067/21/19/7151 |
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