Low bone mineralization in phenylketonuria may be due to undiagnosed metabolic acidosis

Low bone mineralization in phenylketonuria may be due to undiagnosed metabolic acidosis

Background: Dietary intervention is to date the mainstay treatment to prevent toxic phenylalanine (Phe) accumulation in PKU patients. Despite success preventing central nervous system damage, there is increasing evidence of possible other unfavorable outcomes affecting other systems, e.g. kidney and...

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Bibliographic Details
Main Authors: Valentina Rovelli, Vittoria Ercoli, Alice Re Dionigi, Sabrina Paci, Elisabetta Salvatici, Juri Zuvadelli, Giuseppe Banderali
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
PKU
Metabolic acidosis
PRAL
Bone mass density
Dietary interventions
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426923000447

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