Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment
Ranju Kharel Sitaula,1 Anadi Khatri2 1Uveitis Department, B.P. Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; 2Fellow of Vitreo-Retina Surgery, Lumbini Eye Institute, Siddharthanagar, Nepal Abstract: Bilateral intraocular involvement in La...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-03-01
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| Series: | International Medical Case Reports Journal |
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| Online Access: | https://www.dovepress.com/langerhans-cell-histiocytosis-with-hemorrhagic-uveitis-and-exudative-r-peer-reviewed-article-IMCRJ |
| _version_ | 1818143243601182720 |
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| author | Kharel Sitaula R Khatri A |
| author_facet | Kharel Sitaula R Khatri A |
| author_sort | Kharel Sitaula R |
| collection | DOAJ |
| description | Ranju Kharel Sitaula,1 Anadi Khatri2 1Uveitis Department, B.P. Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; 2Fellow of Vitreo-Retina Surgery, Lumbini Eye Institute, Siddharthanagar, Nepal Abstract: Bilateral intraocular involvement in Langerhans cell histiocytosis (LCH) is uncommon. A 15-year-old boy presented with painless decreased vision in right and painful left red eye of 2 weeks duration. Visual acuity was 20/500 and 20/200, respectively. A fixed dilated pupil with exudative retinal detachment was present in the right eye and hemorrhagic iris nodules with hyphema and hypopyon were seen in the left eye. Intraocular pressure was 12 and 31 mmHg, respectively, in each eye. Ocular symptoms were preceded by fever with multiple skin rashes, subcutaneous nodules, and lymph node enlargement. The histopathological examination of skin and lymph node showed histiocytes positive for histiocytic S 100. He was treated with topical steroids and antiglaucoma eye drops along with intravenous vinblastine 6 mg and oral prednisolone (1 mg/kg). Hyphema and hypopyon were resolved, vision improved to 20/320 and 20/80, and intraocular pressure was under control. However, as multisystemic LCH has a poor prognosis, we were unable to save him. Hence, fatal conditions like LCH should also be considered in the differential diagnosis of any hemorrhagic uveitis. Keywords: exudative retinal detachment, uveitis, langerhans cell histiocytosis, bilateral, IL-17 |
| first_indexed | 2024-12-11T11:28:34Z |
| format | Article |
| id | doaj.art-9a6b79266069473ebc8b2a0c7b126d8a |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-12-11T11:28:34Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-9a6b79266069473ebc8b2a0c7b126d8a2022-12-22T01:08:56ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2018-03-01Volume 11656837435Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachmentKharel Sitaula RKhatri ARanju Kharel Sitaula,1 Anadi Khatri2 1Uveitis Department, B.P. Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; 2Fellow of Vitreo-Retina Surgery, Lumbini Eye Institute, Siddharthanagar, Nepal Abstract: Bilateral intraocular involvement in Langerhans cell histiocytosis (LCH) is uncommon. A 15-year-old boy presented with painless decreased vision in right and painful left red eye of 2 weeks duration. Visual acuity was 20/500 and 20/200, respectively. A fixed dilated pupil with exudative retinal detachment was present in the right eye and hemorrhagic iris nodules with hyphema and hypopyon were seen in the left eye. Intraocular pressure was 12 and 31 mmHg, respectively, in each eye. Ocular symptoms were preceded by fever with multiple skin rashes, subcutaneous nodules, and lymph node enlargement. The histopathological examination of skin and lymph node showed histiocytes positive for histiocytic S 100. He was treated with topical steroids and antiglaucoma eye drops along with intravenous vinblastine 6 mg and oral prednisolone (1 mg/kg). Hyphema and hypopyon were resolved, vision improved to 20/320 and 20/80, and intraocular pressure was under control. However, as multisystemic LCH has a poor prognosis, we were unable to save him. Hence, fatal conditions like LCH should also be considered in the differential diagnosis of any hemorrhagic uveitis. Keywords: exudative retinal detachment, uveitis, langerhans cell histiocytosis, bilateral, IL-17https://www.dovepress.com/langerhans-cell-histiocytosis-with-hemorrhagic-uveitis-and-exudative-r-peer-reviewed-article-IMCRJExudative Retinal DetachmentUveitisLangerhans Cell Histiocytosis. |
| spellingShingle | Kharel Sitaula R Khatri A Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment International Medical Case Reports Journal Exudative Retinal Detachment Uveitis Langerhans Cell Histiocytosis. |
| title | Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment |
| title_full | Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment |
| title_fullStr | Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment |
| title_full_unstemmed | Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment |
| title_short | Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment |
| title_sort | langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment |
| topic | Exudative Retinal Detachment Uveitis Langerhans Cell Histiocytosis. |
| url | https://www.dovepress.com/langerhans-cell-histiocytosis-with-hemorrhagic-uveitis-and-exudative-r-peer-reviewed-article-IMCRJ |
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