Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma

Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma

Complement component C1q can act as a pro-tumorigenic factor in the tumor microenvironment (TME). The TME in malignant pleural mesothelioma (MPM) is rich in C1q and hyaluronic acid (HA), whose interaction enhances adhesion, migration and proliferation of malignant cells. HA-bound C1q is also capable...

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Bibliographic Details
Main Authors: Andrea Balduit, Romana Vidergar, Paola Zacchi, Alessandro Mangogna, Chiara Agostinis, Micaela Grandolfo, Cristina Bottin, Francesco Salton, Paola Confalonieri, Andrea Rocca, Fabrizio Zanconati, Marco Confalonieri, Uday Kishore, Berhane Ghebrehiwet, Roberta Bulla
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
hyaluronic acid
hyaluronidase
C1q
HYAL2
gC1qR/HABP1/p32
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151194/full

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