Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study
Saengshik is a type of meal-replacement product or dietary supplement comprising an uncooked and dried plant-based food mixture with various health-promoting properties, such as antidiabetic, anti-dyslipidemic, antioxidant, and anticancer properties. Although these properties are considered attribut...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.743620/full |
| _version_ | 1819027836637282304 |
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| author | Ji-Hee Shin Yong Ju Ahn Won-Hyong Chung Won-Hyong Chung Mi Young Lim Seungpyo Hong Joong-Hark Kim Joong-Hark Kim Mi Houn Park Young-Do Nam |
| author_facet | Ji-Hee Shin Yong Ju Ahn Won-Hyong Chung Won-Hyong Chung Mi Young Lim Seungpyo Hong Joong-Hark Kim Joong-Hark Kim Mi Houn Park Young-Do Nam |
| author_sort | Ji-Hee Shin |
| collection | DOAJ |
| description | Saengshik is a type of meal-replacement product or dietary supplement comprising an uncooked and dried plant-based food mixture with various health-promoting properties, such as antidiabetic, anti-dyslipidemic, antioxidant, and anticancer properties. Although these properties are considered attributable to the various bioactive components absorbed through the intestine and its remolding effect on intestinal microorganisms, the effect of Saengshik supplementation on gut microbiota profiles has not yet been studied. In this study, we investigated the effect of Saengshik administration on the composition of gut microbiota. This single-group design trial was conducted on 102 healthy men and women who received 40 g/day of Saengshik powder for 8 weeks, during which stool samples were collected at two fixed time points (baseline and the endpoint) for gut microbiota-profiling analysis. We observed a significant decrease in the α-diversity of gut microbiota after Saengshik consumption (P < 0.05), with significant changes identified in the composition of major microbial taxa, such as Bacteroidetes (P < 0.0001), Proteobacteria, Actinobacteria, and Verrucomicrobia (P < 0.0001). Notably, the gut microbial response was related to the inter-individual variability of habitual dietary intake and enterotype at baseline. To the best of our knowledge, this is the first study investigating the effects of Saengshik intake on changes in gut microbiota, with the results suggesting that individual habitual diet patterns and gut microbial shapes should be considered key aspects in Saengshik-mediated health-promotion effects. |
| first_indexed | 2024-12-21T05:48:48Z |
| format | Article |
| id | doaj.art-9a6eab9d107a452aa58e26eec4b3adc1 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-21T05:48:48Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-9a6eab9d107a452aa58e26eec4b3adc12022-12-21T19:14:03ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-10-01810.3389/fnut.2021.743620743620Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot StudyJi-Hee Shin0Yong Ju Ahn1Won-Hyong Chung2Won-Hyong Chung3Mi Young Lim4Seungpyo Hong5Joong-Hark Kim6Joong-Hark Kim7Mi Houn Park8Young-Do Nam9Research Group of Healthcare, Korea Food Research Institute, Wanju-gun, South KoreaTheragen Bio Co., Ltd., Seongnam-si, South KoreaResearch Group of Healthcare, Korea Food Research Institute, Wanju-gun, South KoreaDepartment of Food Biotechnology, Korea University of Science and Technology, Daejeon, South KoreaResearch Group of Healthcare, Korea Food Research Institute, Wanju-gun, South KoreaResearch Group of Healthcare, Korea Food Research Institute, Wanju-gun, South KoreaErom R&D Center, Erom Co., Ltd., Chuncheon-si, South KoreaDepartment of Medical Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon-si, South KoreaErom R&D Center, Erom Co., Ltd., Chuncheon-si, South KoreaResearch Group of Healthcare, Korea Food Research Institute, Wanju-gun, South KoreaSaengshik is a type of meal-replacement product or dietary supplement comprising an uncooked and dried plant-based food mixture with various health-promoting properties, such as antidiabetic, anti-dyslipidemic, antioxidant, and anticancer properties. Although these properties are considered attributable to the various bioactive components absorbed through the intestine and its remolding effect on intestinal microorganisms, the effect of Saengshik supplementation on gut microbiota profiles has not yet been studied. In this study, we investigated the effect of Saengshik administration on the composition of gut microbiota. This single-group design trial was conducted on 102 healthy men and women who received 40 g/day of Saengshik powder for 8 weeks, during which stool samples were collected at two fixed time points (baseline and the endpoint) for gut microbiota-profiling analysis. We observed a significant decrease in the α-diversity of gut microbiota after Saengshik consumption (P < 0.05), with significant changes identified in the composition of major microbial taxa, such as Bacteroidetes (P < 0.0001), Proteobacteria, Actinobacteria, and Verrucomicrobia (P < 0.0001). Notably, the gut microbial response was related to the inter-individual variability of habitual dietary intake and enterotype at baseline. To the best of our knowledge, this is the first study investigating the effects of Saengshik intake on changes in gut microbiota, with the results suggesting that individual habitual diet patterns and gut microbial shapes should be considered key aspects in Saengshik-mediated health-promotion effects.https://www.frontiersin.org/articles/10.3389/fnut.2021.743620/fullgut microbiotaraw-food formulaplant-based dietary supplemententerotypeSaengshik |
| spellingShingle | Ji-Hee Shin Yong Ju Ahn Won-Hyong Chung Won-Hyong Chung Mi Young Lim Seungpyo Hong Joong-Hark Kim Joong-Hark Kim Mi Houn Park Young-Do Nam Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study Frontiers in Nutrition gut microbiota raw-food formula plant-based dietary supplement enterotype Saengshik |
| title | Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study |
| title_full | Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study |
| title_fullStr | Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study |
| title_full_unstemmed | Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study |
| title_short | Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study |
| title_sort | effect of saengshik supplementation on the gut microbial composition of healthy korean adults a single group pilot study |
| topic | gut microbiota raw-food formula plant-based dietary supplement enterotype Saengshik |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.743620/full |
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