Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica
Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2016-12-01
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| Series: | Green Processing and Synthesis |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/gps-2016-0049 |
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| author | Tran Tuong Vi Vo Uyen Vy Pham Dong Yen Tran Dai Lam Nguyen Thi Hiep Tran Ngoc Quyen Nguyen Cuu Khoa Thu Le Van Nguyen Dai Hai |
| author_facet | Tran Tuong Vi Vo Uyen Vy Pham Dong Yen Tran Dai Lam Nguyen Thi Hiep Tran Ngoc Quyen Nguyen Cuu Khoa Thu Le Van Nguyen Dai Hai |
| author_sort | Tran Tuong Vi |
| collection | DOAJ |
| description | Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (PNSC@APEG) was successfully prepared with spherical shape and diameter around 50 nm, determined by transmission electron microscopy (TEM). In addition, 5-FU was efficiently trapped in PNSC@APEG particles, which were around 63.4%±3.8% and was slowly released up to 3 days in phosphate buffer saline (PBS). Furthermore, the cell proliferation kit I (MTT) assay data showed that PNSC@APEG was a biocompatible nanocarrier. These results indicated that PNSC@APEG nanoparticles have a great potential as novel carriers for anticancer drug delivery. |
| first_indexed | 2024-12-20T03:10:47Z |
| format | Article |
| id | doaj.art-9a6ebd93287546918ac65c1c6d72e6f1 |
| institution | Directory Open Access Journal |
| issn | 2191-9542 2191-9550 |
| language | English |
| last_indexed | 2024-12-20T03:10:47Z |
| publishDate | 2016-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Green Processing and Synthesis |
| spelling | doaj.art-9a6ebd93287546918ac65c1c6d72e6f12022-12-21T19:55:29ZengDe GruyterGreen Processing and Synthesis2191-95422191-95502016-12-015652152810.1515/gps-2016-0049Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilicaTran Tuong Vi0Vo Uyen Vy1Pham Dong Yen2Tran Dai Lam3Nguyen Thi Hiep4Tran Ngoc Quyen5Nguyen Cuu Khoa6Thu Le Van7Nguyen Dai Hai8Institute of Research and Development, Duy Tan University, Da Nang City 550000, Viet NamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet NamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet NamGraduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Viet NamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University -HCMC (VNU-HCMC), HCMC 70000, Viet NamInstitute of Research and Development, Duy Tan University, Da Nang City 550000, Viet NamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet NamInstitute of Chemistry-Biology and Professional Documents, Ministry of Public Security, 44 Yet Kieu, Hoan Kiem, Hanoi, Viet NamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet NamPorous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (PNSC@APEG) was successfully prepared with spherical shape and diameter around 50 nm, determined by transmission electron microscopy (TEM). In addition, 5-FU was efficiently trapped in PNSC@APEG particles, which were around 63.4%±3.8% and was slowly released up to 3 days in phosphate buffer saline (PBS). Furthermore, the cell proliferation kit I (MTT) assay data showed that PNSC@APEG was a biocompatible nanocarrier. These results indicated that PNSC@APEG nanoparticles have a great potential as novel carriers for anticancer drug delivery.https://doi.org/10.1515/gps-2016-00495-fluorouracilcancer therapydrug delivery systemsporous nanosilica |
| spellingShingle | Tran Tuong Vi Vo Uyen Vy Pham Dong Yen Tran Dai Lam Nguyen Thi Hiep Tran Ngoc Quyen Nguyen Cuu Khoa Thu Le Van Nguyen Dai Hai Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica Green Processing and Synthesis 5-fluorouracil cancer therapy drug delivery systems porous nanosilica |
| title | Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica |
| title_full | Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica |
| title_fullStr | Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica |
| title_full_unstemmed | Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica |
| title_short | Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica |
| title_sort | supramolecular chemistry at interfaces host guest interactions for attaching peg and 5 fluorouracil to the surface of porous nanosilica |
| topic | 5-fluorouracil cancer therapy drug delivery systems porous nanosilica |
| url | https://doi.org/10.1515/gps-2016-0049 |
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