Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children
Objective To investigate the application value of 99mtechnetium-hydrazinonicotinyl-tyr 3-octreotide (99mTc-HTOC) imaging in the diagnosis and staging of neuroblastoma (NB) in children. Methods 99mTc-HTOC scintigraphy was performed on 32 NB suspected children who received at least 1 conventional imag...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2019-07-01
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| Series: | Di-san junyi daxue xuebao |
| Subjects: | |
| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/201812134.htm |
| _version_ | 1819084615682359296 |
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| author | XIONG Yalan YUAN Gengbiao ZHENG Chengxi RAO Maohua |
| author_facet | XIONG Yalan YUAN Gengbiao ZHENG Chengxi RAO Maohua |
| author_sort | XIONG Yalan |
| collection | DOAJ |
| description | Objective To investigate the application value of 99mtechnetium-hydrazinonicotinyl-tyr 3-octreotide (99mTc-HTOC) imaging in the diagnosis and staging of neuroblastoma (NB) in children. Methods 99mTc-HTOC scintigraphy was performed on 32 NB suspected children who received at least 1 conventional imaging examination [ultrasound examination, computed tomography (CT), or magnetic resonance imaging (MRI)] from March 2016 to March 2018 in our hospital. Images were evaluated by 2 experienced nuclear medicine physicians or archiaters. The combination of the results of pathological examination, traditional imaging examination and clinical follow-up were reference standards. Results The sensitivity of 99mTc-HTOC imaging was 96.7% (29/30), specificity was 50% (1/2), positive predictive value was 96.7% (29/30), negative predictive value was 50% (1/2) and diagnostic coincidence rate was 93.8% (30/32). The initial stage was changed in 3 patients (10%) after the 99mTc-HTOC imaging. One of the patients was increased from stage ⅡA to stage Ⅳ, and the remaining 2 patients were increased from stage Ⅲ to stage Ⅳ. Conclusion 99mTc-HTOC imaging improves the accuracy of NB initial staging, and can be used in the diagnosis and staging of NB in children. |
| first_indexed | 2024-12-21T20:51:17Z |
| format | Article |
| id | doaj.art-9a700ecae72a4fd4a472c54e44d966f6 |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-21T20:51:17Z |
| publishDate | 2019-07-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-9a700ecae72a4fd4a472c54e44d966f62022-12-21T18:50:42ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042019-07-0141131275128010.16016/j.1000-5404.201812134Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in childrenXIONG Yalan0YUAN Gengbiao1ZHENG Chengxi2RAO Maohua3Department of Nuclear Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Nuclear Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Nuclear Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Nuclear Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaObjective To investigate the application value of 99mtechnetium-hydrazinonicotinyl-tyr 3-octreotide (99mTc-HTOC) imaging in the diagnosis and staging of neuroblastoma (NB) in children. Methods 99mTc-HTOC scintigraphy was performed on 32 NB suspected children who received at least 1 conventional imaging examination [ultrasound examination, computed tomography (CT), or magnetic resonance imaging (MRI)] from March 2016 to March 2018 in our hospital. Images were evaluated by 2 experienced nuclear medicine physicians or archiaters. The combination of the results of pathological examination, traditional imaging examination and clinical follow-up were reference standards. Results The sensitivity of 99mTc-HTOC imaging was 96.7% (29/30), specificity was 50% (1/2), positive predictive value was 96.7% (29/30), negative predictive value was 50% (1/2) and diagnostic coincidence rate was 93.8% (30/32). The initial stage was changed in 3 patients (10%) after the 99mTc-HTOC imaging. One of the patients was increased from stage ⅡA to stage Ⅳ, and the remaining 2 patients were increased from stage Ⅲ to stage Ⅳ. Conclusion 99mTc-HTOC imaging improves the accuracy of NB initial staging, and can be used in the diagnosis and staging of NB in children.http://aammt.tmmu.edu.cn/Upload/rhtml/201812134.htmoctreotideneuroblastomadiagnosisstagingchildren |
| spellingShingle | XIONG Yalan YUAN Gengbiao ZHENG Chengxi RAO Maohua Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children Di-san junyi daxue xuebao octreotide neuroblastoma diagnosis staging children |
| title | Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children |
| title_full | Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children |
| title_fullStr | Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children |
| title_full_unstemmed | Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children |
| title_short | Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children |
| title_sort | application value of 99mtc htoc in diagnosis and staging of neuroblastoma in children |
| topic | octreotide neuroblastoma diagnosis staging children |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/201812134.htm |
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