Bacteria–Cancer Interface: Awaiting the Perfect Storm
Epidemiological evidence reveal a very close association of malignancies with chronic inflammation as a result of persistent bacterial infection. Recently, more studies have provided experimental evidence for an etiological role of bacterial factors disposing infected tissue towards carcinoma. When...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/10/1321 |
| _version_ | 1797513497760759808 |
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| author | Jonathan Pommer Hansen Waled Mohammed Ali Rajeeve Sivadasan Karthika Rajeeve |
| author_facet | Jonathan Pommer Hansen Waled Mohammed Ali Rajeeve Sivadasan Karthika Rajeeve |
| author_sort | Jonathan Pommer Hansen |
| collection | DOAJ |
| description | Epidemiological evidence reveal a very close association of malignancies with chronic inflammation as a result of persistent bacterial infection. Recently, more studies have provided experimental evidence for an etiological role of bacterial factors disposing infected tissue towards carcinoma. When healthy cells accumulate genomic insults resulting in DNA damage, they may sustain proliferative signalling, resist apoptotic signals, evade growth suppressors, enable replicative immortality, and induce angiogenesis, thus boosting active invasion and metastasis. Moreover, these cells must be able to deregulate cellular energetics and have the ability to evade immune destruction. How bacterial infection leads to mutations and enriches a tumour-promoting inflammatory response or micro-environment is still not clear. In this review we showcase well-studied bacteria and their virulence factors that are tightly associated with carcinoma and the various mechanisms and pathways that could have carcinogenic properties. |
| first_indexed | 2024-03-10T06:17:25Z |
| format | Article |
| id | doaj.art-9a701f49c17649d3857cf5cd1e29e50b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T06:17:25Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-9a701f49c17649d3857cf5cd1e29e50b2023-11-22T19:34:17ZengMDPI AGPathogens2076-08172021-10-011010132110.3390/pathogens10101321Bacteria–Cancer Interface: Awaiting the Perfect StormJonathan Pommer Hansen0Waled Mohammed Ali1Rajeeve Sivadasan2Karthika Rajeeve3Department of Biomedicine, The Skou Building, Høegh-Guldbergs Gade 10, 8000 Aarhus, DenmarkDepartment of Biomedicine, The Skou Building, Høegh-Guldbergs Gade 10, 8000 Aarhus, DenmarkNeurobiology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695014, IndiaDepartment of Biomedicine, The Skou Building, Høegh-Guldbergs Gade 10, 8000 Aarhus, DenmarkEpidemiological evidence reveal a very close association of malignancies with chronic inflammation as a result of persistent bacterial infection. Recently, more studies have provided experimental evidence for an etiological role of bacterial factors disposing infected tissue towards carcinoma. When healthy cells accumulate genomic insults resulting in DNA damage, they may sustain proliferative signalling, resist apoptotic signals, evade growth suppressors, enable replicative immortality, and induce angiogenesis, thus boosting active invasion and metastasis. Moreover, these cells must be able to deregulate cellular energetics and have the ability to evade immune destruction. How bacterial infection leads to mutations and enriches a tumour-promoting inflammatory response or micro-environment is still not clear. In this review we showcase well-studied bacteria and their virulence factors that are tightly associated with carcinoma and the various mechanisms and pathways that could have carcinogenic properties.https://www.mdpi.com/2076-0817/10/10/1321bacteriacancer hallmarksinflammationDNA damageepithelial mesenchymal transition |
| spellingShingle | Jonathan Pommer Hansen Waled Mohammed Ali Rajeeve Sivadasan Karthika Rajeeve Bacteria–Cancer Interface: Awaiting the Perfect Storm Pathogens bacteria cancer hallmarks inflammation DNA damage epithelial mesenchymal transition |
| title | Bacteria–Cancer Interface: Awaiting the Perfect Storm |
| title_full | Bacteria–Cancer Interface: Awaiting the Perfect Storm |
| title_fullStr | Bacteria–Cancer Interface: Awaiting the Perfect Storm |
| title_full_unstemmed | Bacteria–Cancer Interface: Awaiting the Perfect Storm |
| title_short | Bacteria–Cancer Interface: Awaiting the Perfect Storm |
| title_sort | bacteria cancer interface awaiting the perfect storm |
| topic | bacteria cancer hallmarks inflammation DNA damage epithelial mesenchymal transition |
| url | https://www.mdpi.com/2076-0817/10/10/1321 |
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