Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation

Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation

In response to hydrostatic pressure, the cation channel transient receptor potential vanilloid 1 (TRPV1) is essential in signaling pathways linked to glaucoma. When activated, TRPV1 undergoes a gating transition from a closed to an open state that allows the influx of Ca<sup>2+</sup> ion...

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Bibliographic Details
Main Authors: Muhammad Harith Bin Zamri, Yoshihiro Ujihara, Masanori Nakamura, Mohammad R. K. Mofrad, Shukei Sugita
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
glaucoma
hydrostatic pressure
mechanotransduction
molecular mechanics
Online Access:https://www.mdpi.com/1422-0067/23/13/7366

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