Advances in Molecular Pathology of Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the prospective mechanism of upper? airway dilator fatigue and the current breakthroughs. Additionally, we also introduced the m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8422 |
| _version_ | 1827642863381381120 |
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| author | Menghan Zhang Yun Lu Lu Sheng Xinxin Han Liming Yu Weihua Zhang Shangfeng Liu Yuehua Liu |
| author_facet | Menghan Zhang Yun Lu Lu Sheng Xinxin Han Liming Yu Weihua Zhang Shangfeng Liu Yuehua Liu |
| author_sort | Menghan Zhang |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the prospective mechanism of upper? airway dilator fatigue and the current breakthroughs. Additionally, we also introduced the molecular mechanism of OSA in terms of related studies on the main signaling pathways and epigenetics alterations, such as microRNA, long non-coding RNA, and DNA methylation. We also reviewed small molecular compounds, which are potential targets for gene regulations in the future, that are involved in the regulation of OSA. This review will be beneficial to point the way for OSA research within the next decade. |
| first_indexed | 2024-03-09T17:39:51Z |
| format | Article |
| id | doaj.art-9a71e1bb5d1c4ec183ce0f0f4b4cbfab |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:39:51Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9a71e1bb5d1c4ec183ce0f0f4b4cbfab2023-11-24T11:42:00ZengMDPI AGMolecules1420-30492022-12-012723842210.3390/molecules27238422Advances in Molecular Pathology of Obstructive Sleep ApneaMenghan Zhang0Yun Lu1Lu Sheng2Xinxin Han3Liming Yu4Weihua Zhang5Shangfeng Liu6Yuehua Liu7Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, ChinaObstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the prospective mechanism of upper? airway dilator fatigue and the current breakthroughs. Additionally, we also introduced the molecular mechanism of OSA in terms of related studies on the main signaling pathways and epigenetics alterations, such as microRNA, long non-coding RNA, and DNA methylation. We also reviewed small molecular compounds, which are potential targets for gene regulations in the future, that are involved in the regulation of OSA. This review will be beneficial to point the way for OSA research within the next decade.https://www.mdpi.com/1420-3049/27/23/8422obstructive sleep apneamolecular pathogenesispharyngeal muscle fatiguesignaling pathways |
| spellingShingle | Menghan Zhang Yun Lu Lu Sheng Xinxin Han Liming Yu Weihua Zhang Shangfeng Liu Yuehua Liu Advances in Molecular Pathology of Obstructive Sleep Apnea Molecules obstructive sleep apnea molecular pathogenesis pharyngeal muscle fatigue signaling pathways |
| title | Advances in Molecular Pathology of Obstructive Sleep Apnea |
| title_full | Advances in Molecular Pathology of Obstructive Sleep Apnea |
| title_fullStr | Advances in Molecular Pathology of Obstructive Sleep Apnea |
| title_full_unstemmed | Advances in Molecular Pathology of Obstructive Sleep Apnea |
| title_short | Advances in Molecular Pathology of Obstructive Sleep Apnea |
| title_sort | advances in molecular pathology of obstructive sleep apnea |
| topic | obstructive sleep apnea molecular pathogenesis pharyngeal muscle fatigue signaling pathways |
| url | https://www.mdpi.com/1420-3049/27/23/8422 |
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