The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma
Abstract Background Eosinophils are bone marrow-derived granulocytes known to have an imperative role in tissue inflammation. The mechanism of tumour-associated tissue eosinophilia (TATE) in head and neck cancers is however not well understood, and its role as a prognosticator is under evaluation. T...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-08-01
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| Series: | The Egyptian Journal of Otolaryngology |
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| Online Access: | https://doi.org/10.1186/s43163-021-00150-5 |
| _version_ | 1797203652269572096 |
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| author | Naveen Sharma Neha Salaria Surender Kumar Nimmy Thomas Nidhi Beniwal Ranvir Singh |
| author_facet | Naveen Sharma Neha Salaria Surender Kumar Nimmy Thomas Nidhi Beniwal Ranvir Singh |
| author_sort | Naveen Sharma |
| collection | DOAJ |
| description | Abstract Background Eosinophils are bone marrow-derived granulocytes known to have an imperative role in tissue inflammation. The mechanism of tumour-associated tissue eosinophilia (TATE) in head and neck cancers is however not well understood, and its role as a prognosticator is under evaluation. The aim of this study was to evaluate the association of TATE with factors associated with head and neck cancer and to assess its role as a prognostic marker in such patients. Results 102 males and 24 females comprised the study population, and 34.9% of which were in the age group of 41 to 50 years. Amongst these 126 patients, most (37.3%) presented in stage III followed by stage IV (28.6%). 29.4% had well-differentiated SCC, 55.6% had moderately differentiated SCC, and 15% were diagnosed with poorly differentiated SCC. 42.8% had TATE grade II, followed by grade III (29.4%) and grade I (27.8%). Correlation studies showed that factors significantly associated with TATE were age, site and tumour differentiation. While 45.7% poorly differentiated tumours showed grade I eosinophilia, 51.4% of well-differentiated tumours had grade III TATE. Conclusions TATE showed a highly significant association with tumour differentiation, suggestive of eosinophils partaking a tumouricidal role. This association may be utilised as a convenient early prognosticator for head and neck cancers and should be made a regular feature of biopsy reports. Furthermore, it may be utilised in planning and adopting appropriate treatment modalities in malignancies predicted to have an aggressive course. |
| first_indexed | 2024-04-24T08:22:44Z |
| format | Article |
| id | doaj.art-9a720744dc954b1b84222a1cb0f14052 |
| institution | Directory Open Access Journal |
| issn | 1012-5574 2090-8539 |
| language | English |
| last_indexed | 2024-04-24T08:22:44Z |
| publishDate | 2021-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Otolaryngology |
| spelling | doaj.art-9a720744dc954b1b84222a1cb0f140522024-04-17T00:13:39ZengSpringerOpenThe Egyptian Journal of Otolaryngology1012-55742090-85392021-08-013711810.1186/s43163-021-00150-5The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinomaNaveen Sharma0Neha Salaria1Surender Kumar2Nimmy Thomas3Nidhi Beniwal4Ranvir Singh5Department of ENT, BPS Government Medical College for Women Khanpur KalanDepartment of ENT, BPS Government Medical College for Women Khanpur KalanDepartment of ENT, BPS Government Medical College for Women Khanpur KalanDepartment of ENT, BPS Government Medical College for Women Khanpur KalanDepartment of ENT, BPS Government Medical College for Women Khanpur KalanDepartment of ENT, BPS Government Medical College for Women Khanpur KalanAbstract Background Eosinophils are bone marrow-derived granulocytes known to have an imperative role in tissue inflammation. The mechanism of tumour-associated tissue eosinophilia (TATE) in head and neck cancers is however not well understood, and its role as a prognosticator is under evaluation. The aim of this study was to evaluate the association of TATE with factors associated with head and neck cancer and to assess its role as a prognostic marker in such patients. Results 102 males and 24 females comprised the study population, and 34.9% of which were in the age group of 41 to 50 years. Amongst these 126 patients, most (37.3%) presented in stage III followed by stage IV (28.6%). 29.4% had well-differentiated SCC, 55.6% had moderately differentiated SCC, and 15% were diagnosed with poorly differentiated SCC. 42.8% had TATE grade II, followed by grade III (29.4%) and grade I (27.8%). Correlation studies showed that factors significantly associated with TATE were age, site and tumour differentiation. While 45.7% poorly differentiated tumours showed grade I eosinophilia, 51.4% of well-differentiated tumours had grade III TATE. Conclusions TATE showed a highly significant association with tumour differentiation, suggestive of eosinophils partaking a tumouricidal role. This association may be utilised as a convenient early prognosticator for head and neck cancers and should be made a regular feature of biopsy reports. Furthermore, it may be utilised in planning and adopting appropriate treatment modalities in malignancies predicted to have an aggressive course.https://doi.org/10.1186/s43163-021-00150-5EosinophiliaHead and neck cancerTumourTissue |
| spellingShingle | Naveen Sharma Neha Salaria Surender Kumar Nimmy Thomas Nidhi Beniwal Ranvir Singh The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma The Egyptian Journal of Otolaryngology Eosinophilia Head and neck cancer Tumour Tissue |
| title | The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma |
| title_full | The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma |
| title_fullStr | The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma |
| title_full_unstemmed | The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma |
| title_short | The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma |
| title_sort | role of tumour associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma |
| topic | Eosinophilia Head and neck cancer Tumour Tissue |
| url | https://doi.org/10.1186/s43163-021-00150-5 |
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