Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art
Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the pharynx, the larynx, and the sinonasal cavities. There are many associated risk factors, including alcohol drinking coup...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/9/3264 |
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| author | Lara Nokovitch Charles Maquet Frédéric Crampon Ihsène Taihi Lise-Marie Roussel Rais Obongo François Virard Béatrice Fervers Sophie Deneuve |
| author_facet | Lara Nokovitch Charles Maquet Frédéric Crampon Ihsène Taihi Lise-Marie Roussel Rais Obongo François Virard Béatrice Fervers Sophie Deneuve |
| author_sort | Lara Nokovitch |
| collection | DOAJ |
| description | Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the pharynx, the larynx, and the sinonasal cavities. There are many associated risk factors, including alcohol drinking coupled with tobacco use, which accounts for 70% to 80% of HNSCCs. Human papilloma virus (HPV) is another independent risk factor for oropharyngeal SCC, but it is only a minor contributor to oral cavity SCC (OSCC). Betel quid chewing is also an established risk factor in southeast Asian countries. However, OSCC, and especially oral tongue cancer, incidence has been reported to be increasing in several countries, suggesting risk factors that have not been identified yet. This review summarizes the established risk factors for oral cavity squamous cell carcinomas and examines other undemonstrated risk factors for HNSCC. |
| first_indexed | 2024-03-11T04:15:23Z |
| format | Article |
| id | doaj.art-9a74d9ba8b594ead9f741dfc39bf8c48 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:15:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9a74d9ba8b594ead9f741dfc39bf8c482023-11-17T23:12:53ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-01129326410.3390/jcm12093264Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the ArtLara Nokovitch0Charles Maquet1Frédéric Crampon2Ihsène Taihi3Lise-Marie Roussel4Rais Obongo5François Virard6Béatrice Fervers7Sophie Deneuve8Department of Otolaryngology-Head and Neck Surgery, CHU Rouen, 76000 Rouen, FranceDepartment of Otolaryngology-Head and Neck Surgery, CHU Rouen, 76000 Rouen, FranceDepartment of Otolaryngology-Head and Neck Surgery, CHU Rouen, 76000 Rouen, FranceOral Surgery Department, Rothschild Hospital, 75012 Paris, FranceDepartment of Head and Neck Cancer and ENT Surgery, Centre Henri Becquerel, 76038 Rouen, FranceDepartment of Head and Neck Cancer and ENT Surgery, Centre Henri Becquerel, 76038 Rouen, FranceINSERM U1052-CNRS UMR5286, Cancer Research Center, Centre Léon Bérard, University Claude Bernard Lyon 1, 69008 Lyon, FranceDépartement Prévention Cancer Environnement, Centre Léon Bérard, 69008 Lyon, FranceDepartment of Otolaryngology-Head and Neck Surgery, CHU Rouen, 76000 Rouen, FranceHead and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the pharynx, the larynx, and the sinonasal cavities. There are many associated risk factors, including alcohol drinking coupled with tobacco use, which accounts for 70% to 80% of HNSCCs. Human papilloma virus (HPV) is another independent risk factor for oropharyngeal SCC, but it is only a minor contributor to oral cavity SCC (OSCC). Betel quid chewing is also an established risk factor in southeast Asian countries. However, OSCC, and especially oral tongue cancer, incidence has been reported to be increasing in several countries, suggesting risk factors that have not been identified yet. This review summarizes the established risk factors for oral cavity squamous cell carcinomas and examines other undemonstrated risk factors for HNSCC.https://www.mdpi.com/2077-0383/12/9/3264oral cancersquamous cell carcinomarisk factoroccupational exposureIARC |
| spellingShingle | Lara Nokovitch Charles Maquet Frédéric Crampon Ihsène Taihi Lise-Marie Roussel Rais Obongo François Virard Béatrice Fervers Sophie Deneuve Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art Journal of Clinical Medicine oral cancer squamous cell carcinoma risk factor occupational exposure IARC |
| title | Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art |
| title_full | Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art |
| title_fullStr | Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art |
| title_full_unstemmed | Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art |
| title_short | Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art |
| title_sort | oral cavity squamous cell carcinoma risk factors state of the art |
| topic | oral cancer squamous cell carcinoma risk factor occupational exposure IARC |
| url | https://www.mdpi.com/2077-0383/12/9/3264 |
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