VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway

VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway

Abstract Background CD4+ cytotoxic T cells (CD4 CTLs) are CD4+ T cells with major histocompatibility complex-II-restricted cytotoxic function. Under pathologic conditions, CD4 CTLs hasten the development of autoimmune disease or viral infection by enhancing cytotoxicity. However, the regulators of t...

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Bibliographic Details
Main Authors: Ziyi Chen, Meng Zhang, Yufeng Liu, Zhe Chen, Ling Wang, Wenjuan Wang, Jincheng Wang, Mingqian He, Bingyin Shi, Yue Wang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
CD4+ cytotoxic T cells
CD4 CTLs
VEGF-A
VEGF-R1
VEGF-R2
mTOR
Online Access:https://doi.org/10.1186/s12967-023-03926-w

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