Assessment of Phenotype Relevant Amino Acid Residues in TEM-β-Lactamases by Mathematical Modelling and Experimental Approval
Single substitutions or combinations of them alter the hydrolytic activity towards specific β-lactam-antibiotics and β-lactamase inhibitors of TEM-β-lactamases. The sequences and phenotypic classification of allelic TEM variants, as provided by the NCBI National Database of Antibiotic Resistant Orga...
Main Authors: | Sara Madzgalla, Helena Duering, Jana C. Hey, Svetlana Neubauer, Karl-Heinz Feller, Ralf Ehricht, Mathias W. Pletz, Oliwia Makarewicz |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
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Series: | Microorganisms |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-2607/9/8/1726 |
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