Assessment of Phenotype Relevant Amino Acid Residues in TEM-β-Lactamases by Mathematical Modelling and Experimental Approval

Assessment of Phenotype Relevant Amino Acid Residues in TEM-β-Lactamases by Mathematical Modelling and Experimental Approval

Single substitutions or combinations of them alter the hydrolytic activity towards specific β-lactam-antibiotics and β-lactamase inhibitors of TEM-β-lactamases. The sequences and phenotypic classification of allelic TEM variants, as provided by the NCBI National Database of Antibiotic Resistant Orga...

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Bibliographic Details
Main Authors:	Sara Madzgalla, Helena Duering, Jana C. Hey, Svetlana Neubauer, Karl-Heinz Feller, Ralf Ehricht, Mathias W. Pletz, Oliwia Makarewicz
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Microorganisms
Subjects:	antimicrobial resistance Gram-negative bacteria molecular diagnostics extended-spectrum beta-lactamases beta-lactamase-inhibitor
Online Access:	https://www.mdpi.com/2076-2607/9/8/1726

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