Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics?
Cellular therapy is a promising tool of human medicine to successfully treat complex and challenging pathologies such as cardiovascular diseases or chronic inflammatory conditions. Bone marrow-derived mesenchymal stromal cells (BMSCs) are in the limelight of these efforts, initially, trying to explo...
| প্রধান লেখক: | , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
MDPI AG
2021-08-01
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| মালা: | Cells |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.mdpi.com/2073-4409/10/9/2199 |
| _version_ | 1829453137412358144 |
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| author | Dhir Gala Sidhesh Mohak Zsolt Fábián |
| author_facet | Dhir Gala Sidhesh Mohak Zsolt Fábián |
| author_sort | Dhir Gala |
| collection | DOAJ |
| description | Cellular therapy is a promising tool of human medicine to successfully treat complex and challenging pathologies such as cardiovascular diseases or chronic inflammatory conditions. Bone marrow-derived mesenchymal stromal cells (BMSCs) are in the limelight of these efforts, initially, trying to exploit their natural properties by direct transplantation. Extensive research on the therapeutic use of BMSCs shed light on a number of key aspects of BMSC physiology including the importance of oxygen in the control of BMSC phenotype. These efforts also led to a growing number of evidence indicating that the beneficial therapeutic effects of BMSCs can be mediated by BMSC-secreted agents. Further investigations revealed that BMSC-excreted extracellular vesicles could mediate the potentially therapeutic effects of BMSCs. Here, we review our current understanding of the relationship between low oxygen conditions and the effects of BMSC-secreted extracellular vesicles focusing on the possible medical relevance of this interplay. |
| first_indexed | 2024-03-10T07:49:33Z |
| format | Article |
| id | doaj.art-9a76de2d0b0942aab5fdea6e48b99e5a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:49:33Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9a76de2d0b0942aab5fdea6e48b99e5a2023-11-22T12:22:24ZengMDPI AGCells2073-44092021-08-01109219910.3390/cells10092199Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics?Dhir Gala0Sidhesh Mohak1Zsolt Fábián2Department of Molecular Cell Biology, School of Medicine, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UKDepartment of Molecular Cell Biology, School of Medicine, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UKDepartment of Molecular Cell Biology, School of Medicine, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UKCellular therapy is a promising tool of human medicine to successfully treat complex and challenging pathologies such as cardiovascular diseases or chronic inflammatory conditions. Bone marrow-derived mesenchymal stromal cells (BMSCs) are in the limelight of these efforts, initially, trying to exploit their natural properties by direct transplantation. Extensive research on the therapeutic use of BMSCs shed light on a number of key aspects of BMSC physiology including the importance of oxygen in the control of BMSC phenotype. These efforts also led to a growing number of evidence indicating that the beneficial therapeutic effects of BMSCs can be mediated by BMSC-secreted agents. Further investigations revealed that BMSC-excreted extracellular vesicles could mediate the potentially therapeutic effects of BMSCs. Here, we review our current understanding of the relationship between low oxygen conditions and the effects of BMSC-secreted extracellular vesicles focusing on the possible medical relevance of this interplay.https://www.mdpi.com/2073-4409/10/9/2199bone marrow-derived stromal cellshypoxiaextracellular vesicles |
| spellingShingle | Dhir Gala Sidhesh Mohak Zsolt Fábián Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics? Cells bone marrow-derived stromal cells hypoxia extracellular vesicles |
| title | Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics? |
| title_full | Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics? |
| title_fullStr | Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics? |
| title_full_unstemmed | Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics? |
| title_short | Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics? |
| title_sort | extracellular vehicles of oxygen depleted mesenchymal stromal cells route to off shelf cellular therapeutics |
| topic | bone marrow-derived stromal cells hypoxia extracellular vesicles |
| url | https://www.mdpi.com/2073-4409/10/9/2199 |
| work_keys_str_mv | AT dhirgala extracellularvehiclesofoxygendepletedmesenchymalstromalcellsroutetooffshelfcellulartherapeutics AT sidheshmohak extracellularvehiclesofoxygendepletedmesenchymalstromalcellsroutetooffshelfcellulartherapeutics AT zsoltfabian extracellularvehiclesofoxygendepletedmesenchymalstromalcellsroutetooffshelfcellulartherapeutics |