Experimental rat models for contrast-induced nephropathy; a comprehensive review
Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (CM). A number of agents are currently being assessed to minimise or prevent CIN. Such agents are typically assessed using rat models. The aim of this study was to provide...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2020-04-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-9-e12.pdf |
| _version_ | 1797827990314287104 |
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| author | Marlon Perera Joseph Ischia Damien Bolton Arthur Shulkes Graham S. Baldwin Oneel Patel |
| author_facet | Marlon Perera Joseph Ischia Damien Bolton Arthur Shulkes Graham S. Baldwin Oneel Patel |
| author_sort | Marlon Perera |
| collection | DOAJ |
| description | Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (CM). A number of agents are currently being assessed to minimise or prevent CIN. Such agents are typically assessed using rat models. The aim of this study was to provide a comprehensive review of the rat models of CIN used in pre-clinical research. The MEDLINE, EMBASE, Web of Science and Cochrane databases were systematically searched. Articles reporting rat models of CIN were included for assessment. Study designs, contrast agents and outcome measures were assessed. Of the assessed studies, a majority report a requirement for pre-existing renal impairment prior to the administration of CM. Outcome measures are heterogenous between studies, but typically include assessment and quantification of serum biochemical markers, cellular oxidative stress and histopathological changes. The significant variation in methodology reported in the current literature highlights the lack of consensus. The use of a reliable pre-contrast insult appears critical to result in the development of contrast nephropathy. The use of acceptable outcome measures appears to include serum laboratory markers, quantification of reactive oxygen species (ROS) and objective histopathological outcomes. |
| first_indexed | 2024-04-09T12:57:18Z |
| format | Article |
| id | doaj.art-9a77a513f43044248702525d7a84a286 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:18Z |
| publishDate | 2020-04-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-9a77a513f43044248702525d7a84a2862023-05-13T11:26:49ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192020-04-0192e12e1210.34172/jnp.2020.12jnp-9838Experimental rat models for contrast-induced nephropathy; a comprehensive reviewMarlon Perera0Joseph Ischia1Damien Bolton2Arthur Shulkes3Graham S. Baldwin4Oneel Patel5University of Melbourne Department of Surgery, Austin Health, Victoria, AustraliaUniversity of Melbourne Department of Surgery, Austin Health, Victoria, AustraliaUniversity of Melbourne Department of Surgery, Austin Health, Victoria, AustraliaUniversity of Melbourne Department of Surgery, Austin Health, Victoria, AustraliaUniversity of Melbourne Department of Surgery, Austin Health, Victoria, AustraliaUniversity of Melbourne Department of Surgery, Austin Health, Victoria, AustraliaContrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (CM). A number of agents are currently being assessed to minimise or prevent CIN. Such agents are typically assessed using rat models. The aim of this study was to provide a comprehensive review of the rat models of CIN used in pre-clinical research. The MEDLINE, EMBASE, Web of Science and Cochrane databases were systematically searched. Articles reporting rat models of CIN were included for assessment. Study designs, contrast agents and outcome measures were assessed. Of the assessed studies, a majority report a requirement for pre-existing renal impairment prior to the administration of CM. Outcome measures are heterogenous between studies, but typically include assessment and quantification of serum biochemical markers, cellular oxidative stress and histopathological changes. The significant variation in methodology reported in the current literature highlights the lack of consensus. The use of a reliable pre-contrast insult appears critical to result in the development of contrast nephropathy. The use of acceptable outcome measures appears to include serum laboratory markers, quantification of reactive oxygen species (ROS) and objective histopathological outcomes.https://nephropathol.com/PDF/jnp-9-e12.pdfcontrast-induced nephropathycontrastnephropathykidney injuryrat modelsanimal models |
| spellingShingle | Marlon Perera Joseph Ischia Damien Bolton Arthur Shulkes Graham S. Baldwin Oneel Patel Experimental rat models for contrast-induced nephropathy; a comprehensive review Journal of Nephropathology contrast-induced nephropathy contrast nephropathy kidney injury rat models animal models |
| title | Experimental rat models for contrast-induced nephropathy; a comprehensive review |
| title_full | Experimental rat models for contrast-induced nephropathy; a comprehensive review |
| title_fullStr | Experimental rat models for contrast-induced nephropathy; a comprehensive review |
| title_full_unstemmed | Experimental rat models for contrast-induced nephropathy; a comprehensive review |
| title_short | Experimental rat models for contrast-induced nephropathy; a comprehensive review |
| title_sort | experimental rat models for contrast induced nephropathy a comprehensive review |
| topic | contrast-induced nephropathy contrast nephropathy kidney injury rat models animal models |
| url | https://nephropathol.com/PDF/jnp-9-e12.pdf |
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