Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties

Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties

Abstract Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the greatest obstacle to the successful delivery of drug therapies is the blood brain barrier (BBB). Intracerebrovent...

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Bibliographic Details
Main Authors:	Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Starlyn L. Okada-Rising, Zachary S. Bailey, Anke H. Scultetus, Deborah A. Shear
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Series:	Journal of Translational Medicine
Subjects:	Traumatic brain injury Intranasal drug delivery Mitochondrial function therapeutics Blood brain barrier Neuroprotection
Online Access:	https://doi.org/10.1186/s12967-024-04908-2

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