Drug discovery opportunities at the endothelin B receptor-related orphan G protein-coupled receptors, GPR37 and GPR37L1

Drug discovery opportunities at the endothelin B receptor-related orphan G protein-coupled receptors, GPR37 and GPR37L1

Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery. Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR37 (ET(B)R-LP, Pael-R) and GPR37L1 (ET(B)R-LP-2)....

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Bibliographic Details
Main Author: Nicola J Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Pharmacology
Subjects:
endothelin
GPCR
G protein-coupled receptor
parkin
GPR37
orphan
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00275/full

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