Telomerase Inhibition by Everolimus Suppresses Smooth Muscle Cell Proliferation and Neointima Formation Through Epigenetic Gene Silencing

Telomerase Inhibition by Everolimus Suppresses Smooth Muscle Cell Proliferation and Neointima Formation Through Epigenetic Gene Silencing

Proliferation of smooth muscle cells (SMCs) during neointima formation is prevented by drug-eluting stents. The replicative capacity of mammalian cells is enhanced by telomerase expression; however, the contribution of telomerase to the proliferative response underlying neointima formation and its p...

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Bibliographic Details
Main Authors: Jun Aono, MD, PhD, Ernesto Ruiz-Rodriguez, MD, Hua Qing, MD, Hannes M. Findeisen, MD, Karrie L. Jones, BS, Elizabeth B. Heywood, MS, Dennis Bruemmer, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:JACC: Basic to Translational Science
Subjects:
everolimus
neointima
smooth muscle cell
telomerase
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16000061

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