Regulatory T cells control immune responses through their nonredundant tissue specific features
Regulatory T cells (Treg) are needed to control immune responses and to maintain immune homeostasis. Most potent regulators are Foxp3 expressing CD4+ T cells which can be roughly divided in to two main groups, natural Treg cells (nTreg) developing in the thymus and induced or adaptive Treg cells (iT...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00294/full |
| _version_ | 1811283079521632256 |
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| author | Sari eLehtimäki Riitta eLahesmaa |
| author_facet | Sari eLehtimäki Riitta eLahesmaa |
| author_sort | Sari eLehtimäki |
| collection | DOAJ |
| description | Regulatory T cells (Treg) are needed to control immune responses and to maintain immune homeostasis. Most potent regulators are Foxp3 expressing CD4+ T cells which can be roughly divided in to two main groups, natural Treg cells (nTreg) developing in the thymus and induced or adaptive Treg cells (iTreg) developing in the periphery from naïve, conventional T cells. Both nTreg cells and iTreg cells have their own, nonredundant roles in the immune system, with nTreg cells mainly maintaining tolerance towards self-structures and iTreg developing in response to externally delivered antigens or commensal microbes. In addition, Treg cells acquire tissue specific features and are adapted to function in the tissue they reside. This review will focus on some specific features of Treg cells in different compartments of the body. |
| first_indexed | 2024-04-13T02:05:07Z |
| format | Article |
| id | doaj.art-9a7b91dddb5b4a008bb0f26bc3ae47e7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T02:05:07Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9a7b91dddb5b4a008bb0f26bc3ae47e72022-12-22T03:07:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-09-01410.3389/fimmu.2013.0029463668Regulatory T cells control immune responses through their nonredundant tissue specific featuresSari eLehtimäki0Riitta eLahesmaa1Turku Centre for BiotechnologyTurku Centre for BiotechnologyRegulatory T cells (Treg) are needed to control immune responses and to maintain immune homeostasis. Most potent regulators are Foxp3 expressing CD4+ T cells which can be roughly divided in to two main groups, natural Treg cells (nTreg) developing in the thymus and induced or adaptive Treg cells (iTreg) developing in the periphery from naïve, conventional T cells. Both nTreg cells and iTreg cells have their own, nonredundant roles in the immune system, with nTreg cells mainly maintaining tolerance towards self-structures and iTreg developing in response to externally delivered antigens or commensal microbes. In addition, Treg cells acquire tissue specific features and are adapted to function in the tissue they reside. This review will focus on some specific features of Treg cells in different compartments of the body.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00294/fullImmunitySystems BiologytolerancemicrobiotaRegulatory T Celltissue specificity |
| spellingShingle | Sari eLehtimäki Riitta eLahesmaa Regulatory T cells control immune responses through their nonredundant tissue specific features Frontiers in Immunology Immunity Systems Biology tolerance microbiota Regulatory T Cell tissue specificity |
| title | Regulatory T cells control immune responses through their nonredundant tissue specific features |
| title_full | Regulatory T cells control immune responses through their nonredundant tissue specific features |
| title_fullStr | Regulatory T cells control immune responses through their nonredundant tissue specific features |
| title_full_unstemmed | Regulatory T cells control immune responses through their nonredundant tissue specific features |
| title_short | Regulatory T cells control immune responses through their nonredundant tissue specific features |
| title_sort | regulatory t cells control immune responses through their nonredundant tissue specific features |
| topic | Immunity Systems Biology tolerance microbiota Regulatory T Cell tissue specificity |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00294/full |
| work_keys_str_mv | AT sarielehtimaki regulatorytcellscontrolimmuneresponsesthroughtheirnonredundanttissuespecificfeatures AT riittaelahesmaa regulatorytcellscontrolimmuneresponsesthroughtheirnonredundanttissuespecificfeatures |