Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential
Arabinoxylan is a polysaccharide of Plantago ovata, an indigenous plant of Pakistan and several European countries. In the present investigation arabinoxylan isolated from P. ovata husk was chemically modified i.e., carboxymethylated and was converted into its sodium salt. Physicochemical characteri...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-09-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/23788 |
| _version_ | 1819042962973130752 |
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| author | Alia Erum Sajid Bashir Shazia Saghir |
| author_facet | Alia Erum Sajid Bashir Shazia Saghir |
| author_sort | Alia Erum |
| collection | DOAJ |
| description | Arabinoxylan is a polysaccharide of Plantago ovata, an indigenous plant of Pakistan and several European countries. In the present investigation arabinoxylan isolated from P. ovata husk was chemically modified i.e., carboxymethylated and was converted into its sodium salt. Physicochemical characterization of modified arabinoxylans was done. The antimicrobial assay of arabinoxylan and modified arabinoxylans was done by Kirby-Bauer disk diffusion method against Gram negative and Gram positive bacterial strains. Physicochemical properties of modified arabinoxylans were different from arabinoxylan yet were satisfactory for their use as pharmaceutical excipients. Arabinoxylan showed strong antimicrobial activity against Gram positive strains. However, it showed no antimicrobial activity against Gram negative strains. Carboxymethyl arabinoxylan showed maximum activity against S. epidermidis. It also showed activity against S. aureus and P. aeruginosa. Arabinoxylan-Na showed concentration-dependent antimicrobial activity. This study provides the first report on the antibacterial properties of arabinoxylan and its modified forms. |
| first_indexed | 2024-12-21T09:49:14Z |
| format | Article |
| id | doaj.art-9a7c266b30054d67a44e887bdedd0071 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-21T09:49:14Z |
| publishDate | 2015-09-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-9a7c266b30054d67a44e887bdedd00712022-12-21T19:08:13ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-09-0110410.3329/bjp.v10i4.23788Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potentialAlia Erum0Sajid Bashir1Shazia Saghir2Faculty of Pharmacy, University of Sargodha, SargodhaFaculty of Pharmacy, University of Sargodha, SargodhaDepartment of Chemistry, Government Jinnah Degree College for Women, Mozang, LahoreArabinoxylan is a polysaccharide of Plantago ovata, an indigenous plant of Pakistan and several European countries. In the present investigation arabinoxylan isolated from P. ovata husk was chemically modified i.e., carboxymethylated and was converted into its sodium salt. Physicochemical characterization of modified arabinoxylans was done. The antimicrobial assay of arabinoxylan and modified arabinoxylans was done by Kirby-Bauer disk diffusion method against Gram negative and Gram positive bacterial strains. Physicochemical properties of modified arabinoxylans were different from arabinoxylan yet were satisfactory for their use as pharmaceutical excipients. Arabinoxylan showed strong antimicrobial activity against Gram positive strains. However, it showed no antimicrobial activity against Gram negative strains. Carboxymethyl arabinoxylan showed maximum activity against S. epidermidis. It also showed activity against S. aureus and P. aeruginosa. Arabinoxylan-Na showed concentration-dependent antimicrobial activity. This study provides the first report on the antibacterial properties of arabinoxylan and its modified forms.https://www.banglajol.info/index.php/BJP/article/view/23788AntimicrobialArabinoxylanArabinoxylan-NaCarboxymethyl arabinoxylan |
| spellingShingle | Alia Erum Sajid Bashir Shazia Saghir Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential Bangladesh Journal of Pharmacology Antimicrobial Arabinoxylan Arabinoxylan-Na Carboxymethyl arabinoxylan |
| title | Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential |
| title_full | Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential |
| title_fullStr | Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential |
| title_full_unstemmed | Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential |
| title_short | Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential |
| title_sort | modified and unmodified arabinoxylans from plantago ovata husk novel excipients with antimicrobial potential |
| topic | Antimicrobial Arabinoxylan Arabinoxylan-Na Carboxymethyl arabinoxylan |
| url | https://www.banglajol.info/index.php/BJP/article/view/23788 |
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