High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome
Background: Polycystic ovarian syndrome (PCOS) is a common disease among women in fertility ages and cause severe insulin resistance. Hyperhomocysteinaemia is said to be among the features of PCOS that could influence its outcome.Objective: This study aimed to investigate whether hyperhomocysteinaem...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science, Yazd, Iran
2011-01-01
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| Series: | Iranian Journal of Reproductive Medicine |
| Subjects: | |
| Online Access: | http://www.ijrm.ir/library/upload/article/af_295233510)%2089-27-5.pdf |
| _version_ | 1828279403021336576 |
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| author | Tayebe Hemati Nasrin Moghadami-Tabrizi Fateme Davari-Tanha Bahram Salmanian Pouya Javadian |
| author_facet | Tayebe Hemati Nasrin Moghadami-Tabrizi Fateme Davari-Tanha Bahram Salmanian Pouya Javadian |
| author_sort | Tayebe Hemati |
| collection | DOAJ |
| description | Background: Polycystic ovarian syndrome (PCOS) is a common disease among women in fertility ages and cause severe insulin resistance. Hyperhomocysteinaemia is said to be among the features of PCOS that could influence its outcome.Objective: This study aimed to investigate whether hyperhomocysteinaemia exists in PCOS and if it is related to insulin resistance in the affected patients.Materials and Methods: This prospective study was carried out in a university based fertility clinic. Sixty four PCOS patients and 50 normo ovulatory controls were reviewed for fasting glucose, insulin, homocysteine, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) plasma levels in the blood sample of the 3rd day of their menstrual cycle. Insulin resistance was determined with the fasting glucose (mmol/L) to insulin (mIU/L) ratio and HOMA-IR (Homeostasis model assessment-Insulin resistance). Independent-samples T-test and linear regression test were utilized to analyze the obtained data.Results: Homocysteine levels compared between PCOS patients and control group showed a significant difference. PCOS group was divided into insulin resistant (IR) (LogHOMA-IR≥0.57) and non insulin resistant (NIR) patients. The IR group had significantly higher homocysteine (p-value=0.02), fasting insulin and glucose levels (p-value<0.001) rather than NIR group.Conclusion: PCOS patients have a leaning toward hyperhomocysteinaemia and insulin resistance. Insulin resistant patients are found to have higher homocysteine level |
| first_indexed | 2024-04-13T07:42:42Z |
| format | Article |
| id | doaj.art-9a7c8018330b4f62aab7e2bb9215a41e |
| institution | Directory Open Access Journal |
| issn | 1680-6433 |
| language | English |
| last_indexed | 2024-04-13T07:42:42Z |
| publishDate | 2011-01-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-9a7c8018330b4f62aab7e2bb9215a41e2022-12-22T02:55:49ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332011-01-0193223228High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndromeTayebe HematiNasrin Moghadami-TabriziFateme Davari-TanhaBahram SalmanianPouya JavadianBackground: Polycystic ovarian syndrome (PCOS) is a common disease among women in fertility ages and cause severe insulin resistance. Hyperhomocysteinaemia is said to be among the features of PCOS that could influence its outcome.Objective: This study aimed to investigate whether hyperhomocysteinaemia exists in PCOS and if it is related to insulin resistance in the affected patients.Materials and Methods: This prospective study was carried out in a university based fertility clinic. Sixty four PCOS patients and 50 normo ovulatory controls were reviewed for fasting glucose, insulin, homocysteine, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) plasma levels in the blood sample of the 3rd day of their menstrual cycle. Insulin resistance was determined with the fasting glucose (mmol/L) to insulin (mIU/L) ratio and HOMA-IR (Homeostasis model assessment-Insulin resistance). Independent-samples T-test and linear regression test were utilized to analyze the obtained data.Results: Homocysteine levels compared between PCOS patients and control group showed a significant difference. PCOS group was divided into insulin resistant (IR) (LogHOMA-IR≥0.57) and non insulin resistant (NIR) patients. The IR group had significantly higher homocysteine (p-value=0.02), fasting insulin and glucose levels (p-value<0.001) rather than NIR group.Conclusion: PCOS patients have a leaning toward hyperhomocysteinaemia and insulin resistance. Insulin resistant patients are found to have higher homocysteine levelhttp://www.ijrm.ir/library/upload/article/af_295233510)%2089-27-5.pdfPCOSHomocysteineInsulin resistanceInfertility |
| spellingShingle | Tayebe Hemati Nasrin Moghadami-Tabrizi Fateme Davari-Tanha Bahram Salmanian Pouya Javadian High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome Iranian Journal of Reproductive Medicine PCOS Homocysteine Insulin resistance Infertility |
| title | High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome |
| title_full | High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome |
| title_fullStr | High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome |
| title_full_unstemmed | High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome |
| title_short | High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome |
| title_sort | high plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome |
| topic | PCOS Homocysteine Insulin resistance Infertility |
| url | http://www.ijrm.ir/library/upload/article/af_295233510)%2089-27-5.pdf |
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