Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism
BackgroundThe intraoperative parathyroid hormone (IOPTH) assay is widely used in patients with primary hyperparathyroidism (PHPT). We investigated the usefulness of the IOPTH assay in Korean patients with PHPT.MethodsWe retrospectively reviewed the data of 33 patients with PHPT who underwent parathy...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2014-12-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-464.pdf |
| _version_ | 1818345223486439424 |
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| author | Eirie Cho Jung Mi Chang Seok Young Yoon Gil Tae Lee Yun Hyi Ku Hong Il Kim Myung-Chul Lee Guk Haeng Lee Min Joo Kim |
| author_facet | Eirie Cho Jung Mi Chang Seok Young Yoon Gil Tae Lee Yun Hyi Ku Hong Il Kim Myung-Chul Lee Guk Haeng Lee Min Joo Kim |
| author_sort | Eirie Cho |
| collection | DOAJ |
| description | BackgroundThe intraoperative parathyroid hormone (IOPTH) assay is widely used in patients with primary hyperparathyroidism (PHPT). We investigated the usefulness of the IOPTH assay in Korean patients with PHPT.MethodsWe retrospectively reviewed the data of 33 patients with PHPT who underwent parathyroidectomy. Neck ultrasonography (US) and 99mTc-sestamibi scintigraphy (MIBI scan) were performed preoperatively and IOPTH assays were conducted.ResultsThe sensitivity of neck US and MIBI scans were 91% and 94%, respectively. A 50% decrease in parathyroid hormone (PTH) levels 10 minutes after excision of the parathyroid gland was obtained in 91% (30/33) of patients and operative success was achieved in 97% (32/33) of patients. The IOPTH assay was 91% true-positive, 3% true-negative, 0% false-positive, and 6% false-negative. The overall accuracy of the IOPTH assay was 94%. In five cases with discordant neck US and MIBI scan results, a sufficient decrease in IOPTH levels helped the surgeon confirm the complete excision of the parathyroid gland with no additional neck exploration.ConclusionThe IOPTH assay is an accurate tool for localizing hyperfunctioning parathyroid glands and is helpful for evaluating cases with discordant neck US and MIBI scan results. |
| first_indexed | 2024-12-13T16:58:57Z |
| format | Article |
| id | doaj.art-9a7cc06d450e4838b5b1917b6eb8981e |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T16:58:57Z |
| publishDate | 2014-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-9a7cc06d450e4838b5b1917b6eb8981e2022-12-21T23:37:50ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782014-12-0129446446910.3803/EnM.2014.29.4.46421210Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary HyperparathyroidismEirie ChoJung Mi ChangSeok Young YoonGil Tae LeeYun Hyi KuHong Il KimMyung-Chul LeeGuk Haeng LeeMin Joo KimBackgroundThe intraoperative parathyroid hormone (IOPTH) assay is widely used in patients with primary hyperparathyroidism (PHPT). We investigated the usefulness of the IOPTH assay in Korean patients with PHPT.MethodsWe retrospectively reviewed the data of 33 patients with PHPT who underwent parathyroidectomy. Neck ultrasonography (US) and 99mTc-sestamibi scintigraphy (MIBI scan) were performed preoperatively and IOPTH assays were conducted.ResultsThe sensitivity of neck US and MIBI scans were 91% and 94%, respectively. A 50% decrease in parathyroid hormone (PTH) levels 10 minutes after excision of the parathyroid gland was obtained in 91% (30/33) of patients and operative success was achieved in 97% (32/33) of patients. The IOPTH assay was 91% true-positive, 3% true-negative, 0% false-positive, and 6% false-negative. The overall accuracy of the IOPTH assay was 94%. In five cases with discordant neck US and MIBI scan results, a sufficient decrease in IOPTH levels helped the surgeon confirm the complete excision of the parathyroid gland with no additional neck exploration.ConclusionThe IOPTH assay is an accurate tool for localizing hyperfunctioning parathyroid glands and is helpful for evaluating cases with discordant neck US and MIBI scan results.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-464.pdfParathyroid hormoneParathyroid neoplasmsHyperparathyroidism, primaryTechnetium Tc 99m sestamibiUltrasonography |
| spellingShingle | Eirie Cho Jung Mi Chang Seok Young Yoon Gil Tae Lee Yun Hyi Ku Hong Il Kim Myung-Chul Lee Guk Haeng Lee Min Joo Kim Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism Endocrinology and Metabolism Parathyroid hormone Parathyroid neoplasms Hyperparathyroidism, primary Technetium Tc 99m sestamibi Ultrasonography |
| title | Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism |
| title_full | Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism |
| title_fullStr | Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism |
| title_full_unstemmed | Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism |
| title_short | Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism |
| title_sort | preoperative localization and intraoperative parathyroid hormone assay in korean patients with primary hyperparathyroidism |
| topic | Parathyroid hormone Parathyroid neoplasms Hyperparathyroidism, primary Technetium Tc 99m sestamibi Ultrasonography |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-464.pdf |
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