Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study
Background: Behçet’s disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwe...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/9/3149 |
| _version_ | 1797602317360431104 |
|---|---|
| author | Fanny Urbain Isabelle Hardy-Léger Ghaidaa Adebs-Nasser Mathilde de Menthon Cécile Pivert Aude Mausoléo Ariane Laparra Nathalie Lerolle Paul-Albert Domnariu Olivier Lambotte Christian Denier Cécile Goujard Alicia Castro-Gordon Nicolas Noel |
| author_facet | Fanny Urbain Isabelle Hardy-Léger Ghaidaa Adebs-Nasser Mathilde de Menthon Cécile Pivert Aude Mausoléo Ariane Laparra Nathalie Lerolle Paul-Albert Domnariu Olivier Lambotte Christian Denier Cécile Goujard Alicia Castro-Gordon Nicolas Noel |
| author_sort | Fanny Urbain |
| collection | DOAJ |
| description | Background: Behçet’s disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwent a psychometric evaluation with auto- (SCL-90-R and Modified Fatigue Index) and hetero-questionnaires (MINI). A standardized test battery assessed cognitive dysfunction. Data were correlated with BD activity as well as quality of life (SF-36). Results: We included 20 consecutive patients (16 men, four women) with a median [IQR] age of 38 (30.0–45.5) and a median disease duration of 7 years (1.8–11.0). Five patients had an abnormal brain MRI. The SCL-90-R questionnaire highlighted eight psychopathological profiles (42.1%) that correlated with altered quality of life and more severe fatigue. The most frequent symptoms were anxiety (9/19, 47.4%), somatization (8/19, 42.1%) and phobia (5/19, 26.3%). Psychopathological symptoms appeared to be more severe, but not more frequent, in neuro-Behçet’s patients. Based on standardized cognitive evaluation, nine patients had cognitive impairment defined by three or more altered tests. Notably, 6/9 patients did not have any complaint of memory loss and were thus considered ansognostic. Conclusion: Cognitive involvement was significantly associated with BD activity score (BSAS) but not with brain MRI abnormalities. |
| first_indexed | 2024-03-11T04:15:23Z |
| format | Article |
| id | doaj.art-9a7ce31cc5634d1297841da2c653afd7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:15:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9a7ce31cc5634d1297841da2c653afd72023-11-17T23:11:21ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01129314910.3390/jcm12093149Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional StudyFanny Urbain0Isabelle Hardy-Léger1Ghaidaa Adebs-Nasser2Mathilde de Menthon3Cécile Pivert4Aude Mausoléo5Ariane Laparra6Nathalie Lerolle7Paul-Albert Domnariu8Olivier Lambotte9Christian Denier10Cécile Goujard11Alicia Castro-Gordon12Nicolas Noel13Internal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceNeuro-Imaging Department, AP-HP, Groupe Hospitalier Universitaire Paris Saclay Hôpital Bicêtre, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceFaculty of Medicine, Paris Saclay University, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, FranceBackground: Behçet’s disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwent a psychometric evaluation with auto- (SCL-90-R and Modified Fatigue Index) and hetero-questionnaires (MINI). A standardized test battery assessed cognitive dysfunction. Data were correlated with BD activity as well as quality of life (SF-36). Results: We included 20 consecutive patients (16 men, four women) with a median [IQR] age of 38 (30.0–45.5) and a median disease duration of 7 years (1.8–11.0). Five patients had an abnormal brain MRI. The SCL-90-R questionnaire highlighted eight psychopathological profiles (42.1%) that correlated with altered quality of life and more severe fatigue. The most frequent symptoms were anxiety (9/19, 47.4%), somatization (8/19, 42.1%) and phobia (5/19, 26.3%). Psychopathological symptoms appeared to be more severe, but not more frequent, in neuro-Behçet’s patients. Based on standardized cognitive evaluation, nine patients had cognitive impairment defined by three or more altered tests. Notably, 6/9 patients did not have any complaint of memory loss and were thus considered ansognostic. Conclusion: Cognitive involvement was significantly associated with BD activity score (BSAS) but not with brain MRI abnormalities.https://www.mdpi.com/2077-0383/12/9/3149Behçet’s diseasecognitive impairmentneuropsychiatrypsychopathology |
| spellingShingle | Fanny Urbain Isabelle Hardy-Léger Ghaidaa Adebs-Nasser Mathilde de Menthon Cécile Pivert Aude Mausoléo Ariane Laparra Nathalie Lerolle Paul-Albert Domnariu Olivier Lambotte Christian Denier Cécile Goujard Alicia Castro-Gordon Nicolas Noel Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study Journal of Clinical Medicine Behçet’s disease cognitive impairment neuropsychiatry psychopathology |
| title | Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study |
| title_full | Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study |
| title_fullStr | Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study |
| title_full_unstemmed | Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study |
| title_short | Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study |
| title_sort | psychiatric symptoms and cognitive disorders in behcet s disease a single center cross sectional study |
| topic | Behçet’s disease cognitive impairment neuropsychiatry psychopathology |
| url | https://www.mdpi.com/2077-0383/12/9/3149 |
| work_keys_str_mv | AT fannyurbain psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT isabellehardyleger psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT ghaidaaadebsnasser psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT mathildedementhon psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT cecilepivert psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT audemausoleo psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT arianelaparra psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT nathalielerolle psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT paulalbertdomnariu psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT olivierlambotte psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT christiandenier psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT cecilegoujard psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT aliciacastrogordon psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy AT nicolasnoel psychiatricsymptomsandcognitivedisordersinbehcetsdiseaseasinglecentercrosssectionalstudy |