Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study
BackgroundLittle is known about the relationship between the disease activity of Behçet disease (BD) and the incidence of inflammatory major organ events.ObjectivesIn this prospective registry study, we investigated the association between the Behçet Disease Current Activity Form (BDCAF) and inciden...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354969/full |
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| author | Lisa Hirahara Yohei Kirino Yutaro Soejima Yuki Iizuka Ryusuke Yoshimi Yuichiro Fujieda Tatsuya Atsumi Toshihiro Tono Daisuke Kobayashi Akira Meguro Masaki Takeuchi Kentaro Sakamaki Mitsuhiro Takeno Nobuhisa Mizuki Hideaki Nakajima |
| author_facet | Lisa Hirahara Yohei Kirino Yutaro Soejima Yuki Iizuka Ryusuke Yoshimi Yuichiro Fujieda Tatsuya Atsumi Toshihiro Tono Daisuke Kobayashi Akira Meguro Masaki Takeuchi Kentaro Sakamaki Mitsuhiro Takeno Nobuhisa Mizuki Hideaki Nakajima |
| author_sort | Lisa Hirahara |
| collection | DOAJ |
| description | BackgroundLittle is known about the relationship between the disease activity of Behçet disease (BD) and the incidence of inflammatory major organ events.ObjectivesIn this prospective registry study, we investigated the association between the Behçet Disease Current Activity Form (BDCAF) and incidence of inflammatory major organ events, defined as the inflammation of the ocular, central nervous, intestinal, and vascular systems in BD.MethodsWe enrolled participants from Japanese multicenter prospective cohorts. The BDCAF was evaluated annually. BD-related symptoms, including inflammatory major organ events, were monitored. The association between BDCAF and inflammatory major organ events was analyzed by time-to-event analysis. An unsupervised clustering of the participants’ BDCAF, therapeutic agents, and multiple serum cytokines was also performed to examine their association with inflammatory major organ events.ResultsA total of 260 patients were included. The patients had a median BDCAF score of 2 [Interquartile range, 1-3] at the enrolment and remained disease active at 1- and 2-year follow-ups, indicating residual disease activity in BD. Patients with a BDCAF score of 0 had a longer inflammatory major organ event-free survival at 52 weeks than those with a score of 1 or higher (p=2.2 x 10-4). Clustering analysis revealed that patients who did not achieve remission despite treatment with tumor necrosis factor inhibitors had high serum inflammatory cytokine levels and incidences of inflammatory major organ events. Among the elevated cytokines, IL-6 was associated with inflammatory major organ events.ConclusionThis study suggests that treatment strategies targeting overall disease activity and monitoring residual serum IL-6 may help prevent inflammatory major organ events in BD. |
| first_indexed | 2024-04-24T09:33:24Z |
| format | Article |
| id | doaj.art-9a7d9d367d9d48429979cef6e6126f97 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T09:33:24Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9a7d9d367d9d48429979cef6e6126f972024-04-15T13:06:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13549691354969Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry studyLisa Hirahara0Yohei Kirino1Yutaro Soejima2Yuki Iizuka3Ryusuke Yoshimi4Yuichiro Fujieda5Tatsuya Atsumi6Toshihiro Tono7Daisuke Kobayashi8Akira Meguro9Masaki Takeuchi10Kentaro Sakamaki11Mitsuhiro Takeno12Nobuhisa Mizuki13Hideaki Nakajima14Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of General Medicine, Kitasato University School of Medicine, Sagamihara, JapanDivision of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, JapanFaculty of Health Data Science, Juntendo University, Urayasu, JapanDepartment of Allergy and Rheumatology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanBackgroundLittle is known about the relationship between the disease activity of Behçet disease (BD) and the incidence of inflammatory major organ events.ObjectivesIn this prospective registry study, we investigated the association between the Behçet Disease Current Activity Form (BDCAF) and incidence of inflammatory major organ events, defined as the inflammation of the ocular, central nervous, intestinal, and vascular systems in BD.MethodsWe enrolled participants from Japanese multicenter prospective cohorts. The BDCAF was evaluated annually. BD-related symptoms, including inflammatory major organ events, were monitored. The association between BDCAF and inflammatory major organ events was analyzed by time-to-event analysis. An unsupervised clustering of the participants’ BDCAF, therapeutic agents, and multiple serum cytokines was also performed to examine their association with inflammatory major organ events.ResultsA total of 260 patients were included. The patients had a median BDCAF score of 2 [Interquartile range, 1-3] at the enrolment and remained disease active at 1- and 2-year follow-ups, indicating residual disease activity in BD. Patients with a BDCAF score of 0 had a longer inflammatory major organ event-free survival at 52 weeks than those with a score of 1 or higher (p=2.2 x 10-4). Clustering analysis revealed that patients who did not achieve remission despite treatment with tumor necrosis factor inhibitors had high serum inflammatory cytokine levels and incidences of inflammatory major organ events. Among the elevated cytokines, IL-6 was associated with inflammatory major organ events.ConclusionThis study suggests that treatment strategies targeting overall disease activity and monitoring residual serum IL-6 may help prevent inflammatory major organ events in BD.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354969/fullBehçet diseasedisease activitydisease registrysystemic vasculitiscluster analysis |
| spellingShingle | Lisa Hirahara Yohei Kirino Yutaro Soejima Yuki Iizuka Ryusuke Yoshimi Yuichiro Fujieda Tatsuya Atsumi Toshihiro Tono Daisuke Kobayashi Akira Meguro Masaki Takeuchi Kentaro Sakamaki Mitsuhiro Takeno Nobuhisa Mizuki Hideaki Nakajima Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study Frontiers in Immunology Behçet disease disease activity disease registry systemic vasculitis cluster analysis |
| title | Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study |
| title_full | Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study |
| title_fullStr | Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study |
| title_full_unstemmed | Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study |
| title_short | Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study |
| title_sort | association of high disease activity and serum il 6 levels with the incidence of inflammatory major organ events in behcet disease a prospective registry study |
| topic | Behçet disease disease activity disease registry systemic vasculitis cluster analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354969/full |
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