Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas?
Abstract After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diag...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-023-04714-z |
| _version_ | 1797453823618318336 |
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| author | Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha |
| author_facet | Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha |
| author_sort | Hellen Gelband |
| collection | DOAJ |
| description | Abstract After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics that fueled the initial progress all face some threats to their effectiveness, and global funding to maintain and increase their use over the long term is not guaranteed. Malaria vaccines are among the most promising new interventions that could accelerate the elimination of malaria. Vaccines are still in early stages of rollout in children, the age group (along with pregnant women) that has been the focus of malaria strategies for a century. At the same time, over the past decade, a case has been made, based largely on evidence from verbal autopsies in at least a few high-transmission areas, that the malaria death rate among adults has been greatly underestimated. Could vaccinating adults help to bring down the adult malaria mortality rate, contribute to reduced transmission, or both? A randomized trial of a malaria vaccine is proposed in Sierra Leone, a highly endemic setting, to shed light on this proposition. |
| first_indexed | 2024-03-09T15:28:26Z |
| format | Article |
| id | doaj.art-9a7db689be4744949791564db0c27cc5 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-03-09T15:28:26Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-9a7db689be4744949791564db0c27cc52023-11-26T12:24:02ZengBMCMalaria Journal1475-28752023-09-012211510.1186/s12936-023-04714-zCould vaccinating adults against malaria materially reduce adult mortality in high-transmission areas?Hellen Gelband0Ronald Carshon-Marsh1Rashid Ansumana2Ibrahim Bob Swaray3Arjun Pandey4Ashley Aimone5Isaac Bogoch6John Eikelboom7Prabhat Jha8Centre for Global Health Research, Unity Health Toronto, University of TorontoDalla Lana School of Public Health, University of TorontoSchool of Community Health Sciences, Njala UniversityCentre for Global Health Research, Unity Health Toronto, University of TorontoDepartment of Medicine, Temerty Faculty of Medicine, University of TorontoCentre for Global Health Research, Unity Health Toronto, University of TorontoDivisions of General Internal Medicine and Infectious Diseases, Toronto General Hospital, University Health NetworkPopulation Health Research Institute, Hamilton Health Sciences, McMaster UniversityCentre for Global Health Research, Unity Health Toronto, University of TorontoAbstract After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics that fueled the initial progress all face some threats to their effectiveness, and global funding to maintain and increase their use over the long term is not guaranteed. Malaria vaccines are among the most promising new interventions that could accelerate the elimination of malaria. Vaccines are still in early stages of rollout in children, the age group (along with pregnant women) that has been the focus of malaria strategies for a century. At the same time, over the past decade, a case has been made, based largely on evidence from verbal autopsies in at least a few high-transmission areas, that the malaria death rate among adults has been greatly underestimated. Could vaccinating adults help to bring down the adult malaria mortality rate, contribute to reduced transmission, or both? A randomized trial of a malaria vaccine is proposed in Sierra Leone, a highly endemic setting, to shed light on this proposition.https://doi.org/10.1186/s12936-023-04714-zMalariaAdult mortalityVaccines |
| spellingShingle | Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? Malaria Journal Malaria Adult mortality Vaccines |
| title | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
| title_full | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
| title_fullStr | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
| title_full_unstemmed | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
| title_short | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
| title_sort | could vaccinating adults against malaria materially reduce adult mortality in high transmission areas |
| topic | Malaria Adult mortality Vaccines |
| url | https://doi.org/10.1186/s12936-023-04714-z |
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