Autocrine Effects of Brain Endothelial Cell-Produced Human Apolipoprotein E on Metabolism and Inflammation in vitro

Autocrine Effects of Brain Endothelial Cell-Produced Human Apolipoprotein E on Metabolism and Inflammation in vitro

Reports of APOE4-associated neurovascular dysfunction during aging and in neurodegenerative disorders has led to ongoing research to identify underlying mechanisms. In this study, we focused on whether the APOE genotype of brain endothelial cells modulates their own phenotype. We utilized a modified...

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Bibliographic Details
Main Authors: Felecia M. Marottoli, Troy N. Trevino, Xue Geng, Zarema Arbieva, Pinal Kanabar, Mark Maienschein-Cline, James C. Lee, Sarah E. Lutz, Leon M. Tai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
apolipoprotein E
brain endothelial cells
metabolism
inflammation
SR9009
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.668296/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.668296/full

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