The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals
<p>Abstract</p> <p>Background</p> <p>Obesity has become a common human disorder associated with significant morbidity and mortality and adverse effects on quality of life. Sequence variants in two candidate genes, <it>FTO</it> and <it>UCP</it>-&l...
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BMC
2012-11-01
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| Series: | BMC Medical Genetics |
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| Online Access: | http://www.biomedcentral.com/1471-2350/13/101 |
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| author | Ramos Adauto V Bastos-Rodrigues Luciana Resende Bruna A Friedman Eitan Campanha-Versiani Luciana Miranda Debora M Sarquis Marta De Marco Luiz |
| author_facet | Ramos Adauto V Bastos-Rodrigues Luciana Resende Bruna A Friedman Eitan Campanha-Versiani Luciana Miranda Debora M Sarquis Marta De Marco Luiz |
| author_sort | Ramos Adauto V |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Obesity has become a common human disorder associated with significant morbidity and mortality and adverse effects on quality of life. Sequence variants in two candidate genes, <it>FTO</it> and <it>UCP</it>-<it>1</it>, have been reported to be overrepresented in obese Caucasian population. The association of these genes polymorphisms with the obesity phenotype in a multiethnic group such as the Brazilian population has not been previously reported.</p> <p>Methods</p> <p>To assess the putative contribution of both <it>FTO</it> and <it>UCP</it>-<it>1</it> to body mass index (BMI) and cardiovascular risk we genotyped SNPs rs9939609 (<it>FTO</it>) and rs6536991, rs22705565 and rs12502572 (<it>UCP</it>-<it>1</it>) from 126 morbidly obese subjects (BMI 42.9 ± 5.6 kg/m<sup>2</sup>, mean ± SE) and 113 normal-weight ethnically matched controls (BMI 22.6 ± 3.5 kg/m<sup>2</sup>, mean ± SE). Waist circumference, blood pressure, glucose and serum lipids were also measured. Each sample was also genotyped for 40 biallelic short insertion/deletion polymorphism (indels) for ethnic assignment and to estimate the proportion of European, African and Amerindian biogeographical ancestry in the Brazilian population.</p> <p>Results</p> <p>Cases did not differ from controls in the proportions of genomic ancestry. The <it>FTO</it> SNP rs9939609 and <it>UCP</it>-<it>1</it> SNP rs6536991 were significantly associated with BMI (p= 0.04 and p<0.0001 respectively). An allele dose dependent tendency was observed for BMI for rs6536991 sample of controls. No other significant associations between any SNP and hypertension, hyperlipidemia and diabetes were noted after correction for BMI and no significant synergistic effect between <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs with obesity were noted. There was not an association between rs9939609 (FTO) and rs6536991 (UCP-1) in with maximum weight loss after 1 year in 94 obese patients who underwent bariatric surgery.</p> <p>Conclusion</p> <p>Our data are consistent with <it>FTO</it> rs9939609 and <it>UCP</it>-<it>1</it> rs6536991 common variants as contributors to obesity in the Brazilian population.</p> |
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| language | English |
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| spelling | doaj.art-9a7e79b26b0f4e399aa8cb320101b3902022-12-21T21:04:05ZengBMCBMC Medical Genetics1471-23502012-11-0113110110.1186/1471-2350-13-101The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individualsRamos Adauto VBastos-Rodrigues LucianaResende Bruna AFriedman EitanCampanha-Versiani LucianaMiranda Debora MSarquis MartaDe Marco Luiz<p>Abstract</p> <p>Background</p> <p>Obesity has become a common human disorder associated with significant morbidity and mortality and adverse effects on quality of life. Sequence variants in two candidate genes, <it>FTO</it> and <it>UCP</it>-<it>1</it>, have been reported to be overrepresented in obese Caucasian population. The association of these genes polymorphisms with the obesity phenotype in a multiethnic group such as the Brazilian population has not been previously reported.</p> <p>Methods</p> <p>To assess the putative contribution of both <it>FTO</it> and <it>UCP</it>-<it>1</it> to body mass index (BMI) and cardiovascular risk we genotyped SNPs rs9939609 (<it>FTO</it>) and rs6536991, rs22705565 and rs12502572 (<it>UCP</it>-<it>1</it>) from 126 morbidly obese subjects (BMI 42.9 ± 5.6 kg/m<sup>2</sup>, mean ± SE) and 113 normal-weight ethnically matched controls (BMI 22.6 ± 3.5 kg/m<sup>2</sup>, mean ± SE). Waist circumference, blood pressure, glucose and serum lipids were also measured. Each sample was also genotyped for 40 biallelic short insertion/deletion polymorphism (indels) for ethnic assignment and to estimate the proportion of European, African and Amerindian biogeographical ancestry in the Brazilian population.</p> <p>Results</p> <p>Cases did not differ from controls in the proportions of genomic ancestry. The <it>FTO</it> SNP rs9939609 and <it>UCP</it>-<it>1</it> SNP rs6536991 were significantly associated with BMI (p= 0.04 and p<0.0001 respectively). An allele dose dependent tendency was observed for BMI for rs6536991 sample of controls. No other significant associations between any SNP and hypertension, hyperlipidemia and diabetes were noted after correction for BMI and no significant synergistic effect between <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs with obesity were noted. There was not an association between rs9939609 (FTO) and rs6536991 (UCP-1) in with maximum weight loss after 1 year in 94 obese patients who underwent bariatric surgery.</p> <p>Conclusion</p> <p>Our data are consistent with <it>FTO</it> rs9939609 and <it>UCP</it>-<it>1</it> rs6536991 common variants as contributors to obesity in the Brazilian population.</p>http://www.biomedcentral.com/1471-2350/13/101FTOUCP-1Morbid obesityBrazilian populationMultiethnic sample |
| spellingShingle | Ramos Adauto V Bastos-Rodrigues Luciana Resende Bruna A Friedman Eitan Campanha-Versiani Luciana Miranda Debora M Sarquis Marta De Marco Luiz The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals BMC Medical Genetics FTO UCP-1 Morbid obesity Brazilian population Multiethnic sample |
| title | The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals |
| title_full | The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals |
| title_fullStr | The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals |
| title_full_unstemmed | The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals |
| title_short | The contribution of <it>FTO</it> and <it>UCP</it>-<it>1</it> SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals |
| title_sort | contribution of it fto it and it ucp it it 1 it snps to extreme obesity diabetes and cardiovascular risk in brazilian individuals |
| topic | FTO UCP-1 Morbid obesity Brazilian population Multiethnic sample |
| url | http://www.biomedcentral.com/1471-2350/13/101 |
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