β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems
β-Lactams in the last thirty years have been viewed as universal acylating agents of serine and cysteine enzymes of both prokaryotic and eukaryotic systems. More recently, their use has been propelled by the COVID-19 pandemic, thus broadening their application as inhibitors of viral enzymes. The ure...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Applied Microbiology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-8007/3/3/43 |
| _version_ | 1797581516403900416 |
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| author | Monika I. Konaklieva Balbina J. Plotkin |
| author_facet | Monika I. Konaklieva Balbina J. Plotkin |
| author_sort | Monika I. Konaklieva |
| collection | DOAJ |
| description | β-Lactams in the last thirty years have been viewed as universal acylating agents of serine and cysteine enzymes of both prokaryotic and eukaryotic systems. More recently, their use has been propelled by the COVID-19 pandemic, thus broadening their application as inhibitors of viral enzymes. The urea-based drugs have been extensively studied as inhibitors of the aforementioned enzymes. The focus of this review is the last decade’s drug discovery strategies, as well as new strategies that show utility in the expansion of β-lactams and ureas in the development of new antimicrobial and antiviral drugs. |
| first_indexed | 2024-03-10T23:05:40Z |
| format | Article |
| id | doaj.art-9a7ebebdcd75492ab84c024583f4a6eb |
| institution | Directory Open Access Journal |
| issn | 2673-8007 |
| language | English |
| last_indexed | 2024-03-10T23:05:40Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Microbiology |
| spelling | doaj.art-9a7ebebdcd75492ab84c024583f4a6eb2023-11-19T09:21:00ZengMDPI AGApplied Microbiology2673-80072023-06-013360562810.3390/applmicrobiol3030043β-Lactams and Ureas as Cross Inhibitors of Prokaryotic SystemsMonika I. Konaklieva0Balbina J. Plotkin1Department of Chemistry, American University, 4400 Massachusetts Ave. NW, Washington, DC 20016, USADepartment of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515, USAβ-Lactams in the last thirty years have been viewed as universal acylating agents of serine and cysteine enzymes of both prokaryotic and eukaryotic systems. More recently, their use has been propelled by the COVID-19 pandemic, thus broadening their application as inhibitors of viral enzymes. The urea-based drugs have been extensively studied as inhibitors of the aforementioned enzymes. The focus of this review is the last decade’s drug discovery strategies, as well as new strategies that show utility in the expansion of β-lactams and ureas in the development of new antimicrobial and antiviral drugs.https://www.mdpi.com/2673-8007/3/3/43β-lactamsureasantimicrobialsantiviralsenzyme inhibitors |
| spellingShingle | Monika I. Konaklieva Balbina J. Plotkin β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems Applied Microbiology β-lactams ureas antimicrobials antivirals enzyme inhibitors |
| title | β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems |
| title_full | β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems |
| title_fullStr | β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems |
| title_full_unstemmed | β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems |
| title_short | β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems |
| title_sort | β lactams and ureas as cross inhibitors of prokaryotic systems |
| topic | β-lactams ureas antimicrobials antivirals enzyme inhibitors |
| url | https://www.mdpi.com/2673-8007/3/3/43 |
| work_keys_str_mv | AT monikaikonaklieva blactamsandureasascrossinhibitorsofprokaryoticsystems AT balbinajplotkin blactamsandureasascrossinhibitorsofprokaryoticsystems |