Prognostic value of brain natriuretic peptide in acute pulmonary embolism
Background: Plasma levels of brain natriuretic peptide (BNP) correlate closely with the pressure and mural tension of the right ventricle and with pulmonary arterial pressure. The relationship between brain natriuretic peptide increase in acute pulmonary embolism (APE) and the increase in mortality...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-10-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763814001423 |
| _version_ | 1828350722739011584 |
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| author | Mahmoud M. El-Habashy Ahmad A. Khamis Ayman M. Abdelhady |
| author_facet | Mahmoud M. El-Habashy Ahmad A. Khamis Ayman M. Abdelhady |
| author_sort | Mahmoud M. El-Habashy |
| collection | DOAJ |
| description | Background: Plasma levels of brain natriuretic peptide (BNP) correlate closely with the pressure and mural tension of the right ventricle and with pulmonary arterial pressure. The relationship between brain natriuretic peptide increase in acute pulmonary embolism (APE) and the increase in mortality and morbidity has frequently been suggested in small studies but its global prognostic performance remains largely undefined.
Methods: BNP levels were determined among the 30 consecutive patients arriving at the emergency department with shortness of breath and moderate to high probability of pulmonary embolism. All patients were subjected to a thorough clinical and physical examination, 12 lead electrocardiography, chest X-ray, echocardiography, laboratory tests including complete blood count, coagulation profile, renal and liver functions, brain natriuretic peptide and multiline computed tomography.
Results: 20 patients were diagnosed with APE. Among them, 7 were diagnosed with massive embolism (group 1) and 13 had mild to moderate embolism (group 2). Among the first group 6 patients died while only 2 patients from the second group died. BNP levels were significantly higher in group 1 (130 ± 15 pg/ml) compared to group 2 (91 ± 7 pg/ml) (P < 0.05) and this was associated also with an increased mortality in group 1.
Conclusion: BNP levels can help predict the severity and possible outcome in patients with pulmonary embolism. |
| first_indexed | 2024-04-14T01:29:12Z |
| format | Article |
| id | doaj.art-9a7f4195517342ca827e4b755f80d529 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-04-14T01:29:12Z |
| publishDate | 2014-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-9a7f4195517342ca827e4b755f80d5292022-12-22T02:20:16ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382014-10-016341035103810.1016/j.ejcdt.2014.06.009Prognostic value of brain natriuretic peptide in acute pulmonary embolismMahmoud M. El-Habashy0Ahmad A. Khamis1Ayman M. Abdelhady2Chest Department, Faculty of Medicine Menoufiya University, EgyptChest Department, Faculty of Medicine Menoufiya University, EgyptCardiology Department, Ain Shams University, EgyptBackground: Plasma levels of brain natriuretic peptide (BNP) correlate closely with the pressure and mural tension of the right ventricle and with pulmonary arterial pressure. The relationship between brain natriuretic peptide increase in acute pulmonary embolism (APE) and the increase in mortality and morbidity has frequently been suggested in small studies but its global prognostic performance remains largely undefined. Methods: BNP levels were determined among the 30 consecutive patients arriving at the emergency department with shortness of breath and moderate to high probability of pulmonary embolism. All patients were subjected to a thorough clinical and physical examination, 12 lead electrocardiography, chest X-ray, echocardiography, laboratory tests including complete blood count, coagulation profile, renal and liver functions, brain natriuretic peptide and multiline computed tomography. Results: 20 patients were diagnosed with APE. Among them, 7 were diagnosed with massive embolism (group 1) and 13 had mild to moderate embolism (group 2). Among the first group 6 patients died while only 2 patients from the second group died. BNP levels were significantly higher in group 1 (130 ± 15 pg/ml) compared to group 2 (91 ± 7 pg/ml) (P < 0.05) and this was associated also with an increased mortality in group 1. Conclusion: BNP levels can help predict the severity and possible outcome in patients with pulmonary embolism.http://www.sciencedirect.com/science/article/pii/S0422763814001423Acute pulmonary embolismBNP |
| spellingShingle | Mahmoud M. El-Habashy Ahmad A. Khamis Ayman M. Abdelhady Prognostic value of brain natriuretic peptide in acute pulmonary embolism Egyptian Journal of Chest Disease and Tuberculosis Acute pulmonary embolism BNP |
| title | Prognostic value of brain natriuretic peptide in acute pulmonary embolism |
| title_full | Prognostic value of brain natriuretic peptide in acute pulmonary embolism |
| title_fullStr | Prognostic value of brain natriuretic peptide in acute pulmonary embolism |
| title_full_unstemmed | Prognostic value of brain natriuretic peptide in acute pulmonary embolism |
| title_short | Prognostic value of brain natriuretic peptide in acute pulmonary embolism |
| title_sort | prognostic value of brain natriuretic peptide in acute pulmonary embolism |
| topic | Acute pulmonary embolism BNP |
| url | http://www.sciencedirect.com/science/article/pii/S0422763814001423 |
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