The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature
Abstract Background Terlipressin is a commonly used drug in cirrhotic patients with acute variceal bleed (AVB) due to its vasoconstrictor effects. Ischemic complications are uncommon adverse events associated with worse outcomes. Case presentation We present a case of alcohol-related cirrhosis, who...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43066-023-00273-9 |
| _version_ | 1797769654254436352 |
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| author | Arpit Shastri Sweta Rose Nikhil Vojjala Naveen Bhagat Arka De |
| author_facet | Arpit Shastri Sweta Rose Nikhil Vojjala Naveen Bhagat Arka De |
| author_sort | Arpit Shastri |
| collection | DOAJ |
| description | Abstract Background Terlipressin is a commonly used drug in cirrhotic patients with acute variceal bleed (AVB) due to its vasoconstrictor effects. Ischemic complications are uncommon adverse events associated with worse outcomes. Case presentation We present a case of alcohol-related cirrhosis, who was started on terlipressin for AVB. However, he developed bilateral lower limb gangrene with ischemic skin necrosis and ultimately succumbed to death. Conclusion Although ischemic adverse events are uncommon with terlipressin, it is important to be aware of these complications as they may be severe and potentially life threatening. |
| first_indexed | 2024-03-12T21:12:10Z |
| format | Article |
| id | doaj.art-9a811a41d2ba4004a2ef46cde52206e0 |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-03-12T21:12:10Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-9a811a41d2ba4004a2ef46cde52206e02023-07-30T11:08:11ZengSpringerOpenEgyptian Liver Journal2090-62262023-07-011311410.1186/s43066-023-00273-9The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literatureArpit Shastri0Sweta Rose1Nikhil Vojjala2Naveen Bhagat3Arka De4Department of Hepatology, Post Graduate Institute of Medical Education and ResearchDepartment of Hepatology, Post Graduate Institute of Medical Education and ResearchDepartment of Internal Medicine, Post Graduate Institute of Medical Education and ResearchDepartment of Hepatology, Post Graduate Institute of Medical Education and ResearchDepartment of Hepatology, Post Graduate Institute of Medical Education and ResearchAbstract Background Terlipressin is a commonly used drug in cirrhotic patients with acute variceal bleed (AVB) due to its vasoconstrictor effects. Ischemic complications are uncommon adverse events associated with worse outcomes. Case presentation We present a case of alcohol-related cirrhosis, who was started on terlipressin for AVB. However, he developed bilateral lower limb gangrene with ischemic skin necrosis and ultimately succumbed to death. Conclusion Although ischemic adverse events are uncommon with terlipressin, it is important to be aware of these complications as they may be severe and potentially life threatening.https://doi.org/10.1186/s43066-023-00273-9VasoconstrictorsVariceal bleedIschemic necrosisGangreneCirrhosis |
| spellingShingle | Arpit Shastri Sweta Rose Nikhil Vojjala Naveen Bhagat Arka De The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature Egyptian Liver Journal Vasoconstrictors Variceal bleed Ischemic necrosis Gangrene Cirrhosis |
| title | The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature |
| title_full | The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature |
| title_fullStr | The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature |
| title_full_unstemmed | The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature |
| title_short | The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature |
| title_sort | dark side of terlipressin a case report of ischemic skin necrosis and review of literature |
| topic | Vasoconstrictors Variceal bleed Ischemic necrosis Gangrene Cirrhosis |
| url | https://doi.org/10.1186/s43066-023-00273-9 |
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