Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015
BackgroundNasopharynx carcinoma (NPC) is the most common malignant tumor of the nasopharynx. Many studies have shown some factors related with the prognosis of NPC patients. Our study aims to evaluate the differences of prognosis between initial and second primary NPC.Material and methodsThe Surveil...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1001849/full |
| _version_ | 1811334517231714304 |
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| author | Tianyi Shen Wenting Cai Tingting Li Donghui Yu Chengda Ren Jing Yu Jing Yu |
| author_facet | Tianyi Shen Wenting Cai Tingting Li Donghui Yu Chengda Ren Jing Yu Jing Yu |
| author_sort | Tianyi Shen |
| collection | DOAJ |
| description | BackgroundNasopharynx carcinoma (NPC) is the most common malignant tumor of the nasopharynx. Many studies have shown some factors related with the prognosis of NPC patients. Our study aims to evaluate the differences of prognosis between initial and second primary NPC.Material and methodsThe Surveillance, Epidemiology, and End Results (SEER) program was used to perform the population-based analysis in NPC patients who were newly diagnosed between 2004 and 2015. Kaplan-Meier and Cox regressions were used to evaluate the effects of primary site on the overall survival (OS), as well as the cancer-specific survival (CSS).ResultsOur study included 5,012 NPC patients: 4,474 initial primary NPC patients and 5,38 s primary NPC patients. Significant differences were observed in sex, age at diagnosis, race, median household income, histological type, American Joint Committee on Cancer (AJCC) stage, N-stage, radiation treatment and chemotherapy between patients with initial and second NPC (P < 0.05). Moreover, the patients with second NPC had longer survival months. In addition, radiation and chemotherapy were recommended both in first and second primary NPC patients.ConclusionWorse prognosis was observed in patients with second primary NPC compared with those with primary NPC in all subgroups of AJCC stage and age at diagnosis. |
| first_indexed | 2024-04-13T17:10:14Z |
| format | Article |
| id | doaj.art-9a82d14ba9864ed9bc60a19f5ffa5c39 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-13T17:10:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Surgery |
| spelling | doaj.art-9a82d14ba9864ed9bc60a19f5ffa5c392022-12-22T02:38:19ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-11-01910.3389/fsurg.2022.10018491001849Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015Tianyi Shen0Wenting Cai1Tingting Li2Donghui Yu3Chengda Ren4Jing Yu5Jing Yu6Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, The Third People’s Hospital of Bengbu, Bengbu, ChinaBackgroundNasopharynx carcinoma (NPC) is the most common malignant tumor of the nasopharynx. Many studies have shown some factors related with the prognosis of NPC patients. Our study aims to evaluate the differences of prognosis between initial and second primary NPC.Material and methodsThe Surveillance, Epidemiology, and End Results (SEER) program was used to perform the population-based analysis in NPC patients who were newly diagnosed between 2004 and 2015. Kaplan-Meier and Cox regressions were used to evaluate the effects of primary site on the overall survival (OS), as well as the cancer-specific survival (CSS).ResultsOur study included 5,012 NPC patients: 4,474 initial primary NPC patients and 5,38 s primary NPC patients. Significant differences were observed in sex, age at diagnosis, race, median household income, histological type, American Joint Committee on Cancer (AJCC) stage, N-stage, radiation treatment and chemotherapy between patients with initial and second NPC (P < 0.05). Moreover, the patients with second NPC had longer survival months. In addition, radiation and chemotherapy were recommended both in first and second primary NPC patients.ConclusionWorse prognosis was observed in patients with second primary NPC compared with those with primary NPC in all subgroups of AJCC stage and age at diagnosis.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1001849/fullnasopharyngeal neoplasmsSEER programsecond primaryinitial primaryprognosis |
| spellingShingle | Tianyi Shen Wenting Cai Tingting Li Donghui Yu Chengda Ren Jing Yu Jing Yu Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 Frontiers in Surgery nasopharyngeal neoplasms SEER program second primary initial primary prognosis |
| title | Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 |
| title_full | Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 |
| title_fullStr | Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 |
| title_full_unstemmed | Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 |
| title_short | Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 |
| title_sort | impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015 |
| topic | nasopharyngeal neoplasms SEER program second primary initial primary prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1001849/full |
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