Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer.

Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer.

Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification of these pathogenic variants is important to identify endometrial cancer patie...

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Bibliographic Details
Main Authors: Ashish Kumar Singh, Bente Talseth-Palmer, Mary McPhillips, Liss Anne Solberg Lavik, Alexandre Xavier, Finn Drabløs, Wenche Sjursen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235613

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