Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease

Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease

ABSTRACTGut microbiota and related metabolites are both crucial factors that significantly influence how individuals with Crohn’s disease respond to immunotherapy. However, little is known about the interplay among gut microbiota, metabolites, Crohn’s disease, and the response to anti-α4β7-integrin...

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Bibliographic Details
Main Authors: Bing Han, Daiyuan Tang, Xiaodan Lv, Junhua Fan, Shiquan Li, Hui Zhu, Jiatong Zhang, Shang Xu, Xiaofang Xu, Ziqian Huang, Zhixi Huang, Guangfu Lin, Lingling Zhan, Xiaoping Lv
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
Gut microbiota
bile acid metabolism
biomarker
Crohn’s disease
immunotherapy responses
Anti-α4β7-integrin
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2310894

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