Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

CAG/CTG trinuncleotide repeats are fragile sequences that when expanded form DNA secondary structures and cause human disease. We evaluated CAG/CTG repeat stability and repair outcomes in histone H2 mutants in S. cerevisiae. Although the two copies of H2A are nearly identical in amino acid sequence,...

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Bibliographic Details
Main Authors: Nealia CM House, Erica J Polleys, Ishtiaque Quasem, Marjorie De la Rosa Mejia, Cailin E Joyce, Oliver Takacsi-Nagy, Jocelyn E Krebs, Stephen M Fuchs, Catherine H Freudenreich
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
histone H2A
CAG trinucleotide repeat
DNA repair
DNA recombination
histone phosphorylation
Online Access:https://elifesciences.org/articles/53362

Internet

https://elifesciences.org/articles/53362

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