Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings
Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are highly specialized subcellular compartments that are shaped by ER subdomains juxtaposed to mitochondria but are biochemically distinct from pure ER and pure mitochondria. MAMs are enriched in enzymes involved in lipid synthesis...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-05-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558617305845 |
| _version_ | 1828443210852073472 |
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| author | Giampaolo Morciano Saverio Marchi Claudia Morganti Luigi Sbano Mart Bittremieux Martijn Kerkhofs Mariangela Corricelli Alberto Danese Agnieszka Karkucinska-Wieckowska Mariusz R. Wieckowski Geert Bultynck Carlotta Giorgi Paolo Pinton |
| author_facet | Giampaolo Morciano Saverio Marchi Claudia Morganti Luigi Sbano Mart Bittremieux Martijn Kerkhofs Mariangela Corricelli Alberto Danese Agnieszka Karkucinska-Wieckowska Mariusz R. Wieckowski Geert Bultynck Carlotta Giorgi Paolo Pinton |
| author_sort | Giampaolo Morciano |
| collection | DOAJ |
| description | Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are highly specialized subcellular compartments that are shaped by ER subdomains juxtaposed to mitochondria but are biochemically distinct from pure ER and pure mitochondria. MAMs are enriched in enzymes involved in lipid synthesis and transport, channels for calcium transfer, and proteins with oncogenic/oncosuppressive functions that modulate cell signaling pathways involved in physiological and pathophysiological processes. The term “cancer” denotes a group of disorders that result from uncontrolled cell growth driven by a mixture of genetic and environmental components. Alterations in MAMs are thought to account for the onset as well as the progression and metastasis of cancer and have been a focus of investigation in recent years. In this review, we present the current state of the art regarding MAM-resident proteins and their relevance, alterations, and deregulating functions in different types of cancer from a cell biology and clinical perspective. |
| first_indexed | 2024-12-10T21:24:55Z |
| format | Article |
| id | doaj.art-9a86411e114c4fd9b691591005cbf848 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-12-10T21:24:55Z |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-9a86411e114c4fd9b691591005cbf8482022-12-22T01:33:00ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862018-05-01205510523Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific SettingsGiampaolo Morciano0Saverio Marchi1Claudia Morganti2Luigi Sbano3Mart Bittremieux4Martijn Kerkhofs5Mariangela Corricelli6Alberto Danese7Agnieszka Karkucinska-Wieckowska8Mariusz R. Wieckowski9Geert Bultynck10Carlotta Giorgi11Paolo Pinton12Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy; Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, ItalyDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, ItalyKU Leuven, Lab. Molecular and Cellular Signaling, Dept. Cellular and Molecular Medicine and Leuven Kanker Instituut, Campus Gasthuisberg O&N 1 Box 802, Herestraat 49, 3000 Leuven, BelgiumKU Leuven, Lab. Molecular and Cellular Signaling, Dept. Cellular and Molecular Medicine and Leuven Kanker Instituut, Campus Gasthuisberg O&N 1 Box 802, Herestraat 49, 3000 Leuven, BelgiumDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, ItalyDepartment of Pathology, The Children's Memorial Health Institute, Warsaw, PolandDepartment of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, PolandKU Leuven, Lab. Molecular and Cellular Signaling, Dept. Cellular and Molecular Medicine and Leuven Kanker Instituut, Campus Gasthuisberg O&N 1 Box 802, Herestraat 49, 3000 Leuven, BelgiumDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy; Address all correspondence to: Paolo Pinton or Carlotta Giorgi, Dept. of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, ItalyDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy; Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy; CNR Institute of Cell Biology and Neurobiology, Monterotondo, Italy; Address all correspondence to: Paolo Pinton or Carlotta Giorgi, Dept. of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, ItalyMitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are highly specialized subcellular compartments that are shaped by ER subdomains juxtaposed to mitochondria but are biochemically distinct from pure ER and pure mitochondria. MAMs are enriched in enzymes involved in lipid synthesis and transport, channels for calcium transfer, and proteins with oncogenic/oncosuppressive functions that modulate cell signaling pathways involved in physiological and pathophysiological processes. The term “cancer” denotes a group of disorders that result from uncontrolled cell growth driven by a mixture of genetic and environmental components. Alterations in MAMs are thought to account for the onset as well as the progression and metastasis of cancer and have been a focus of investigation in recent years. In this review, we present the current state of the art regarding MAM-resident proteins and their relevance, alterations, and deregulating functions in different types of cancer from a cell biology and clinical perspective.http://www.sciencedirect.com/science/article/pii/S1476558617305845 |
| spellingShingle | Giampaolo Morciano Saverio Marchi Claudia Morganti Luigi Sbano Mart Bittremieux Martijn Kerkhofs Mariangela Corricelli Alberto Danese Agnieszka Karkucinska-Wieckowska Mariusz R. Wieckowski Geert Bultynck Carlotta Giorgi Paolo Pinton Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings Neoplasia: An International Journal for Oncology Research |
| title | Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings |
| title_full | Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings |
| title_fullStr | Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings |
| title_full_unstemmed | Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings |
| title_short | Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings |
| title_sort | role of mitochondria associated er membranes in calcium regulation in cancer specific settings |
| url | http://www.sciencedirect.com/science/article/pii/S1476558617305845 |
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