糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关
Abstract Objective To analyze the clinical characteristics of patients with pancreatic cancer (PC) and diabetes and to explore the impact of diabetes duration, weight loss, and hypoglycemic drugs on the tumor biological behavior of PC. Methods This is a retrospective study on patients with PC and di...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13259 |
| _version_ | 1828091267662217216 |
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| author | Minglei Ma Wei Li Lingling Xu Fan Ping Huabing Zhang Yuxiu Li |
| author_facet | Minglei Ma Wei Li Lingling Xu Fan Ping Huabing Zhang Yuxiu Li |
| author_sort | Minglei Ma |
| collection | DOAJ |
| description | Abstract Objective To analyze the clinical characteristics of patients with pancreatic cancer (PC) and diabetes and to explore the impact of diabetes duration, weight loss, and hypoglycemic drugs on the tumor biological behavior of PC. Methods This is a retrospective study on patients with PC and diabetes. Subjects were grouped according to the onset age of PC, distant metastasis, duration of diabetes, degree of weight loss (∆Wt), and type of hypoglycemic drugs. Logistic regression analysis was used to evaluate the association between diabetes duration, weight loss, hypoglycemic drugs, and early‐onset PC, distant metastasis. Results Compared with late‐onset PC, patients with early‐onset PC had a higher proportion of new‐onset DM (35 [79.5%] vs. 217 [46.9%], p < 0.001), smoker, drinker, and more obvious weight loss (8.5 [3.8, 15] kg vs. 5 [0, 10] kg, p < 0.001). Patients with remote metastasis had an earlier diagnosis age, heavier weight loss, lower body mass index, and were more likely to be smokers but had cancer less likely to be localized in the head of pancreas. Regression analysis showed that new‐onset diabetes and weight loss were independently correlated to early‐onset PC: odds ratio (OR) = 3.38 (95% CI 1.36‐8.4, p = 0.09; OR = 1.56 (95% CI 1.16‐2.1), p = 0.003, respectively. In contrast, long‐term diabetes, and heavy weight loss were independently associated with remote metastasis: OR = 3.38 (95% CI 1.36‐8.4, p = 0.09; OR = 1.56 (95% CI 1.16‐2.1), p = 0.003, respectively. Conclusion New‐onset diabetes and weight loss were common presentation and risk factors of early‐onset PC, which required more attention. Long‐term diabetes and heavy weight loss were risk factors contributing to distant metastases, indicating potential risk factors contributing to the adverse prognosis of patients with PC. |
| first_indexed | 2024-04-11T06:09:55Z |
| format | Article |
| id | doaj.art-9a8971dee5294256aaff1815f13a755e |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-11T06:09:55Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-9a8971dee5294256aaff1815f13a755e2022-12-22T04:41:19ZengWileyJournal of Diabetes1753-03931753-04072022-04-0114426127010.1111/1753-0407.13259糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关Minglei Ma0Wei Li1Lingling Xu2Fan Ping3Huabing Zhang4Yuxiu Li5Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing ChinaAbstract Objective To analyze the clinical characteristics of patients with pancreatic cancer (PC) and diabetes and to explore the impact of diabetes duration, weight loss, and hypoglycemic drugs on the tumor biological behavior of PC. Methods This is a retrospective study on patients with PC and diabetes. Subjects were grouped according to the onset age of PC, distant metastasis, duration of diabetes, degree of weight loss (∆Wt), and type of hypoglycemic drugs. Logistic regression analysis was used to evaluate the association between diabetes duration, weight loss, hypoglycemic drugs, and early‐onset PC, distant metastasis. Results Compared with late‐onset PC, patients with early‐onset PC had a higher proportion of new‐onset DM (35 [79.5%] vs. 217 [46.9%], p < 0.001), smoker, drinker, and more obvious weight loss (8.5 [3.8, 15] kg vs. 5 [0, 10] kg, p < 0.001). Patients with remote metastasis had an earlier diagnosis age, heavier weight loss, lower body mass index, and were more likely to be smokers but had cancer less likely to be localized in the head of pancreas. Regression analysis showed that new‐onset diabetes and weight loss were independently correlated to early‐onset PC: odds ratio (OR) = 3.38 (95% CI 1.36‐8.4, p = 0.09; OR = 1.56 (95% CI 1.16‐2.1), p = 0.003, respectively. In contrast, long‐term diabetes, and heavy weight loss were independently associated with remote metastasis: OR = 3.38 (95% CI 1.36‐8.4, p = 0.09; OR = 1.56 (95% CI 1.16‐2.1), p = 0.003, respectively. Conclusion New‐onset diabetes and weight loss were common presentation and risk factors of early‐onset PC, which required more attention. Long‐term diabetes and heavy weight loss were risk factors contributing to distant metastases, indicating potential risk factors contributing to the adverse prognosis of patients with PC.https://doi.org/10.1111/1753-0407.13259胰腺癌糖尿病减肥降糖药物 |
| spellingShingle | Minglei Ma Wei Li Lingling Xu Fan Ping Huabing Zhang Yuxiu Li 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 Journal of Diabetes 胰腺癌 糖尿病 减肥 降糖药物 |
| title | 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 |
| title_full | 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 |
| title_fullStr | 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 |
| title_full_unstemmed | 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 |
| title_short | 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 |
| title_sort | 糖尿病病程及体重减轻与糖尿病患者胰腺癌的发病年龄及远处转移相关 |
| topic | 胰腺癌 糖尿病 减肥 降糖药物 |
| url | https://doi.org/10.1111/1753-0407.13259 |
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