3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications
The development of artificial tissue/organs with the functional maturity of their native equivalents is one of the long-awaited panaceas for the medical and pharmaceutical industries. Advanced 3D cell-printing technology and various functional bioinks are promising technologies in the field of tissu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/20/7757 |
| _version_ | 1797550402792587264 |
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| author | Jongmin Kim Jeong Sik Kong Wonil Han Byoung Soo Kim Dong-Woo Cho |
| author_facet | Jongmin Kim Jeong Sik Kong Wonil Han Byoung Soo Kim Dong-Woo Cho |
| author_sort | Jongmin Kim |
| collection | DOAJ |
| description | The development of artificial tissue/organs with the functional maturity of their native equivalents is one of the long-awaited panaceas for the medical and pharmaceutical industries. Advanced 3D cell-printing technology and various functional bioinks are promising technologies in the field of tissue engineering that have enabled the fabrication of complex 3D living tissue/organs. Various requirements for these tissues, including a complex and large-volume structure, tissue-specific microenvironments, and functional vasculatures, have been addressed to develop engineered tissue/organs with native relevance. Functional tissue/organ constructs have been developed that satisfy such criteria and may facilitate both in vivo replenishment of damaged tissue and the development of reliable in vitro testing platforms for drug development. This review describes key developments in technologies and materials for engineering 3D cell-printed constructs for therapeutic and drug testing applications. |
| first_indexed | 2024-03-10T15:28:47Z |
| format | Article |
| id | doaj.art-9a8c1b909965467a96d0f06e5c3bb84a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:28:47Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9a8c1b909965467a96d0f06e5c3bb84a2023-11-20T17:49:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012120775710.3390/ijms212077573D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing ApplicationsJongmin Kim0Jeong Sik Kong1Wonil Han2Byoung Soo Kim3Dong-Woo Cho4Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaDivision of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaFuture IT Innovation Laboratory, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaThe development of artificial tissue/organs with the functional maturity of their native equivalents is one of the long-awaited panaceas for the medical and pharmaceutical industries. Advanced 3D cell-printing technology and various functional bioinks are promising technologies in the field of tissue engineering that have enabled the fabrication of complex 3D living tissue/organs. Various requirements for these tissues, including a complex and large-volume structure, tissue-specific microenvironments, and functional vasculatures, have been addressed to develop engineered tissue/organs with native relevance. Functional tissue/organ constructs have been developed that satisfy such criteria and may facilitate both in vivo replenishment of damaged tissue and the development of reliable in vitro testing platforms for drug development. This review describes key developments in technologies and materials for engineering 3D cell-printed constructs for therapeutic and drug testing applications.https://www.mdpi.com/1422-0067/21/20/77573D cell printingbioinktisse engineeringregeneration medicinedrug testing platform |
| spellingShingle | Jongmin Kim Jeong Sik Kong Wonil Han Byoung Soo Kim Dong-Woo Cho 3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications International Journal of Molecular Sciences 3D cell printing bioink tisse engineering regeneration medicine drug testing platform |
| title | 3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications |
| title_full | 3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications |
| title_fullStr | 3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications |
| title_full_unstemmed | 3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications |
| title_short | 3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications |
| title_sort | 3d cell printing of tissue organ mimicking constructs for therapeutic and drug testing applications |
| topic | 3D cell printing bioink tisse engineering regeneration medicine drug testing platform |
| url | https://www.mdpi.com/1422-0067/21/20/7757 |
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