Obesogenic diet induces circuit-specific memory deficits in mice
Obesity is associated with neurocognitive dysfunction, including memory deficits. This is particularly worrisome when obesity occurs during adolescence, a maturational period for brain structures critical for cognition. In rodent models, we recently reported that memory impairments induced by obesog...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-03-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/80388 |
| _version_ | 1797278778776354816 |
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| author | Ioannis Bakoyiannis Eva Gunnel Ducourneau Mateo N'diaye Alice Fermigier Celine Ducroix-Crepy Clementine Bosch-Bouju Etienne Coutureau Pierre Trifilieff Guillaume Ferreira |
| author_facet | Ioannis Bakoyiannis Eva Gunnel Ducourneau Mateo N'diaye Alice Fermigier Celine Ducroix-Crepy Clementine Bosch-Bouju Etienne Coutureau Pierre Trifilieff Guillaume Ferreira |
| author_sort | Ioannis Bakoyiannis |
| collection | DOAJ |
| description | Obesity is associated with neurocognitive dysfunction, including memory deficits. This is particularly worrisome when obesity occurs during adolescence, a maturational period for brain structures critical for cognition. In rodent models, we recently reported that memory impairments induced by obesogenic high-fat diet (HFD) intake during the periadolescent period can be reversed by chemogenetic manipulation of the ventral hippocampus (vHPC). Here, we used an intersectional viral approach in HFD-fed male mice to chemogenetically inactivate specific vHPC efferent pathways to nucleus accumbens (NAc) or medial prefrontal cortex (mPFC) during memory tasks. We first demonstrated that HFD enhanced activation of both pathways after training and that our chemogenetic approach was effective in normalizing this activation. Inactivation of the vHPC–NAc pathway rescued HFD-induced deficits in recognition but not location memory. Conversely, inactivation of the vHPC–mPFC pathway restored location but not recognition memory impairments produced by HFD. Either pathway manipulation did not affect exploration or anxiety-like behaviour. These findings suggest that HFD intake throughout adolescence impairs different types of memory through overactivation of specific hippocampal efferent pathways and that targeting these overactive pathways has therapeutic potential. |
| first_indexed | 2024-03-07T16:14:07Z |
| format | Article |
| id | doaj.art-9a8cfacaa4e846e4a7be8c91c0c8c6b9 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-07T16:14:07Z |
| publishDate | 2024-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9a8cfacaa4e846e4a7be8c91c0c8c6b92024-03-04T15:39:22ZengeLife Sciences Publications LtdeLife2050-084X2024-03-011310.7554/eLife.80388Obesogenic diet induces circuit-specific memory deficits in miceIoannis Bakoyiannis0https://orcid.org/0000-0002-6324-7321Eva Gunnel Ducourneau1https://orcid.org/0000-0002-9254-4405Mateo N'diaye2Alice Fermigier3Celine Ducroix-Crepy4Clementine Bosch-Bouju5Etienne Coutureau6https://orcid.org/0000-0001-6695-020XPierre Trifilieff7Guillaume Ferreira8https://orcid.org/0000-0001-5984-8143University of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceUniversity of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33077, Bordeaux, FranceObesity is associated with neurocognitive dysfunction, including memory deficits. This is particularly worrisome when obesity occurs during adolescence, a maturational period for brain structures critical for cognition. In rodent models, we recently reported that memory impairments induced by obesogenic high-fat diet (HFD) intake during the periadolescent period can be reversed by chemogenetic manipulation of the ventral hippocampus (vHPC). Here, we used an intersectional viral approach in HFD-fed male mice to chemogenetically inactivate specific vHPC efferent pathways to nucleus accumbens (NAc) or medial prefrontal cortex (mPFC) during memory tasks. We first demonstrated that HFD enhanced activation of both pathways after training and that our chemogenetic approach was effective in normalizing this activation. Inactivation of the vHPC–NAc pathway rescued HFD-induced deficits in recognition but not location memory. Conversely, inactivation of the vHPC–mPFC pathway restored location but not recognition memory impairments produced by HFD. Either pathway manipulation did not affect exploration or anxiety-like behaviour. These findings suggest that HFD intake throughout adolescence impairs different types of memory through overactivation of specific hippocampal efferent pathways and that targeting these overactive pathways has therapeutic potential.https://elifesciences.org/articles/80388obesityadolescencepathwayshigh-fat diethippocampusconnectivity |
| spellingShingle | Ioannis Bakoyiannis Eva Gunnel Ducourneau Mateo N'diaye Alice Fermigier Celine Ducroix-Crepy Clementine Bosch-Bouju Etienne Coutureau Pierre Trifilieff Guillaume Ferreira Obesogenic diet induces circuit-specific memory deficits in mice eLife obesity adolescence pathways high-fat diet hippocampus connectivity |
| title | Obesogenic diet induces circuit-specific memory deficits in mice |
| title_full | Obesogenic diet induces circuit-specific memory deficits in mice |
| title_fullStr | Obesogenic diet induces circuit-specific memory deficits in mice |
| title_full_unstemmed | Obesogenic diet induces circuit-specific memory deficits in mice |
| title_short | Obesogenic diet induces circuit-specific memory deficits in mice |
| title_sort | obesogenic diet induces circuit specific memory deficits in mice |
| topic | obesity adolescence pathways high-fat diet hippocampus connectivity |
| url | https://elifesciences.org/articles/80388 |
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