High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China
PurposeThe hemoglobin glycation index (HGI) quantifies the mismatch between glycated hemoglobin A1c and average glycemia among individuals. Currently, it is unknown the potential role of HGI in exhaustively evaluating the progression of glucose metabolism/the risk of developing diabetes mellitus. Th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1081520/full |
| _version_ | 1797895419070513152 |
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| author | Lu Lin Lu Lin Anping Wang Xiaomeng Jia Haibin Wang Yan He Yan He Yiming Mu Jingtao Dou |
| author_facet | Lu Lin Lu Lin Anping Wang Xiaomeng Jia Haibin Wang Yan He Yan He Yiming Mu Jingtao Dou |
| author_sort | Lu Lin |
| collection | DOAJ |
| description | PurposeThe hemoglobin glycation index (HGI) quantifies the mismatch between glycated hemoglobin A1c and average glycemia among individuals. Currently, it is unknown the potential role of HGI in exhaustively evaluating the progression of glucose metabolism/the risk of developing diabetes mellitus. Therefore, this study aimed to investigate the association between HGI and the risk of incident diabetes.MethodsA total of 7,345 participants aged at least 40 years and without diabetes were divided into three groups according to the tertile of their baseline HGI level and followed for a median of 3.24 years to track new-onset diabetes. Using multivariate Cox regression analyses, we explored the association between the HGI, both categorized and continuous, and incident diabetes.ResultsDuring follow-up, 742 subjects (263 males and 479 females) developed diabetes mellitus. Higher HGI was associated with an increased risk of diabetes, even when adjusted for confounding factors, and every standard deviation increase in HGI was associated with a significant risk increase of 30.6% for diabetes (hazard ratio 1.306, 95% confidence interval 1.232–1.384).ConclusionsParticipants with a higher HGI were at a higher risk of future diabetes, irrespective of their glycemic conditions. Consequently, HGI may be employed to identify individuals at high risk for diabetes. |
| first_indexed | 2024-04-10T07:25:20Z |
| format | Article |
| id | doaj.art-9a8ee71e241246ac839a308e945e0e73 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T07:25:20Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9a8ee71e241246ac839a308e945e0e732023-02-24T07:53:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.10815201081520High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in ChinaLu Lin0Lu Lin1Anping Wang2Xiaomeng Jia3Haibin Wang4Yan He5Yan He6Yiming Mu7Jingtao Dou8Department of Endocrinology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Endocrinology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaCenter for Endocrine Metabolism and Immune Disease, Beijing Luhe Hospital, Capital Medical University, Beijing, ChinaDepartment of endocrinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, ChinaMunicipal Key Laboratory of Clinical Epidemiology, Beijing, ChinaDepartment of Endocrinology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaPurposeThe hemoglobin glycation index (HGI) quantifies the mismatch between glycated hemoglobin A1c and average glycemia among individuals. Currently, it is unknown the potential role of HGI in exhaustively evaluating the progression of glucose metabolism/the risk of developing diabetes mellitus. Therefore, this study aimed to investigate the association between HGI and the risk of incident diabetes.MethodsA total of 7,345 participants aged at least 40 years and without diabetes were divided into three groups according to the tertile of their baseline HGI level and followed for a median of 3.24 years to track new-onset diabetes. Using multivariate Cox regression analyses, we explored the association between the HGI, both categorized and continuous, and incident diabetes.ResultsDuring follow-up, 742 subjects (263 males and 479 females) developed diabetes mellitus. Higher HGI was associated with an increased risk of diabetes, even when adjusted for confounding factors, and every standard deviation increase in HGI was associated with a significant risk increase of 30.6% for diabetes (hazard ratio 1.306, 95% confidence interval 1.232–1.384).ConclusionsParticipants with a higher HGI were at a higher risk of future diabetes, irrespective of their glycemic conditions. Consequently, HGI may be employed to identify individuals at high risk for diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2023.1081520/fullbiological variationdiabetes mellitusglycated hemoglobin A1chemoglobin glycation indexrisk factor |
| spellingShingle | Lu Lin Lu Lin Anping Wang Xiaomeng Jia Haibin Wang Yan He Yan He Yiming Mu Jingtao Dou High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China Frontiers in Endocrinology biological variation diabetes mellitus glycated hemoglobin A1c hemoglobin glycation index risk factor |
| title | High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China |
| title_full | High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China |
| title_fullStr | High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China |
| title_full_unstemmed | High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China |
| title_short | High hemoglobin glycation index is associated with increased risk of diabetes: A population-based cohort study in China |
| title_sort | high hemoglobin glycation index is associated with increased risk of diabetes a population based cohort study in china |
| topic | biological variation diabetes mellitus glycated hemoglobin A1c hemoglobin glycation index risk factor |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1081520/full |
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